Biomaterial, joint prosthesis using the biomaterial and method of producing the same
The object of the present invention is to provide a joint prosthesis, bearing material and a production method thereof, which suppresses wear in a sliding section and suppresses the production of abrasive powder even during repeated daily operation. To achieve the object, there is provided a biomaterial comprising: a substrate made of metal, alloy or ceramic; and a biocompatible material layer laminated on the substrate, wherein hydroxyl groups are formed on the substrate by surface-treating, while the biocompatible material layer comprises a polymer containing phosphorylcholine groups, the substrate and the biocompatible material layer are bound via a binder layer which is combined with the hydroxyl groups of the substrate and with the biocompatible material layer.
1. A method for producing a biomaterial having a substrate made of a metal, an alloy or a ceramic material and a biocompatible material layer laminated at appropriate positions on the substrate, comprising the steps of:
(a) plasma-treating the substrate made of a metal, an alloy or a ceramic material containing a metal component or a metal oxide capable of forming hydroxyl groups to form hydroxyl groups on the surface of the substrate;
(b) applying a solution containing a binder constituent to the substrate and then drying the solution to form a binder layer thereon, the binder constituent being an organic compound having carboxyl groups on one terminal and methacrylic groups or methylene groups on the other terminal; and
(c) immersing the substrate in a solution containing a biocompatible material and a photo-initiator and then polymerizing the biocompatible material monomer on the binder layer by UV irradiation to graft-coat the biocompatible material layer on the binder layer.
2. The method for producing a biomaterial according to claim 1 , wherein the substrate is made of at least one selected from the group consisting of cobalt-chromium alloy, cobalt-chromium-molybdenum alloy, nickel-chromium alloy, and stainless steel alloy, and the step (a) further comprises a pre-treatment in which a surface of the alloy substrate is treated with nitric acid to increase a concentration of chromium on the surface of the substrate.
3. The method for producing a biomaterial according to claim 2 , wherein the binder is made of at least one selected from the group consisting of 4-methacryloxyethyltrimellitate anhydride and 4-methacryloyloxy ethyl trimellitic acid, while the biocompatible material is made of a polymer containing phosphorylcholine groups,
and the biocompatible material layer is laminated on the substrate by the binder.
4. The method for producing a biomaterial according to claim 2 , wherein the binder layer is made of at least one selected from the group consisting of 4-methacryloxyethyltrimellitate anhydride, 4-methacryloyloxy ethyl trimellitic acid and methacrylic acid, while the biocompatible material layer is made of 2-methacryloyloxyethyl phosphorylcholine,
the methacrylic groups in 4-methacryloxyethyltrimellitate anhydride, 4-methacryloyloxy ethyl trimellitic acid or methacrylic acid react with the methacrylic groups in 2-methacryloyloxyethyl phosphorylcholine into the formation of covalent bonds,
and the biocompatible material layer is laminated on the substrate by carboxyl groups in the binder layer.
5. The method for producing a biomaterial according to claim 2 , wherein the binder layer is made of at least one selected from the group consisting of maleic anhydride and maleic acid, while the biocompatible material layer is made of 2-methacryloyloxyethyl phosphorylcholine,
methacrylic groups in the 2-methacryloyloxyethyl phosphorylcholine monomer are combined with radicals as nucleus for the graft-polymerization, the radicals being produced by cleaving C—H bond in the maleic anhydride or maleic acid,
the biocompatible material layer is laminated on the substrate by carboxyl groups in the binder layer.