Compositions, methods, and devices for the treatment of eye stain
Embodiments provided herein relate to compositions, methods, and devices useful for treating eye stain. More particularly, compositions and devices are provided that include tylosin and a carrier suitable for ophthalmic application. Such compositions and devices can be used to treat eye stain in an animal, such as a dog or cat.
1. A method of reducing eye stain in a subject comprising:
identifying an animal in need of treatment for eye stain, and
topically administering a composition comprising a therapeutically effective amount of tylosin or a pharmaceutically acceptable salt thereof to the eye of the animal, wherein the administration of the composition reduces eye stain.
2. The method of claim 1 , wherein administration of the composition is effective to reduce bacterial or yeast infection of the eye, thereby reducing the eye stain.
3. The method of claim 2 , wherein the bacterial infection is a Ptyrosporin infection.
4. The method of claim 2 , wherein the yeast infection is a Red Yeast infection.
5. The method of claim 1 , wherein the pharmaceutically acceptable salt is tylosin tartrate.
6. The method of claim 5 , wherein the tylosin is present at a concentration from about 0.1 mg/ml to about 50 mg/ml.
7. The method of claim 1 , wherein the composition further comprises an ophthalmic demulcent, and a carrier suitable for ophthalmic application.
8. The method of claim 7 , wherein the demulcent is selected from the group consisting of carboxymethylcellulose, hydroxyethylcellulose, hypromellose, methylcellulose, dextran, gelatin, glycerin, polyethylene glycol, polysorbate, propylene glycol, polyvinyl alcohol, and providone.
9. The method of claim 7 , wherein said carrier suitable for ophthalmic application is a solution comprising an isotonic agent.
10. The method of claim 7 , wherein said carrier suitable for ophthalmic application is a plurality of microspheres, each microsphere comprising:
a core comprising the tylosin; and
a bioadhesive coat.
11. The method of claim 7 , wherein the composition further comprises a preservative.
12. The method of claim 7 , wherein the tylosin is present at a concentration from about 0.1 mg/ml to about 50 mg/ml.
13. The method of claim 1 , wherein the tylosin is present at a concentration from about 0.1 mg/ml to about 50 mg/ml.
14. The method of claim 1 , wherein the composition comprises:
about 0.1 mg/ml to about 500 mg/ml tylosin tartrate, glycerin, polyethylene glycol, ethylene-diamine-tetra-acetic acid, sodium chloride and benzalkonium chloride.
15. The method of claim 14 , wherein the composition comprises:
about 50 mg/ml tylosin tartrate.
16. The method of claim 1 , wherein the animal is a cat or dog.