Substituted chroman derivatives, medicaments and use in therapy
Novel substituted chroman derivatives and intermediate compounds, compositions containing same, methods for their preparation and uses thereof as therapeutic agents particularly as anti-cancer and chemotherapeutic selective agents are described.
1. A method for the treatment of cancer or a tumour mass, which comprises administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I-b):
wherein
R 1 is C 1-6 alkyl;
the drawing “ ” and R 2 together represent a double bond;
R 3 , R 4 and R 5 are independently hydrogen, hydroxy, C 1-6 alkoxy, or C 1-6 alkyl;
R 6 is hydrogen;
R 7 is C 1-6 alkoxy;
R 8 and R 9 are independently hydrogen, hydroxy, halo, C 1-6 alkoxy, or C 1-6 alkyl;
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the cancer or tumour mass is of epithelial origin, of mesenchymal origin, or of neural origin.
3. The method of claim 2 , wherein the cancer or tumour mass of epithelial origin is prostate, ovarian, cervical, breast, gall-bladder, pancreatic, colorectal, renal, or non-small lung cancer.
4. The method of claim 2 , wherein the cancer or tumour mass of mesenchymal origin is melanoma, mesothelioma, or sarcoma cancer.
5. The method of claim 2 , wherein the cancer or tumour mass of neural origin is glioma.
6. The method of claim 1 , wherein the compound is simultaneously administered with an anti-cancer agent.
7. The method of claim 1 , wherein the compound is sequentially administered with an anti-cancer agent.
8. The method of claim 6 , wherein the anti-cancer agent is cisplatin, dehydroequol, or paclitaxel.
9. The method of claim 7 , wherein the anti-cancer agent is cisplatin, dehydroequol, or paclitaxel.