Beta sheet tapes ribbons in tissue engineering
There is described a material comprising tapes, ribbons, fibrils or fibers characterized in that each of the ribbons, fibrils or fibers have an antiparallel arrangement of peptides in a β-sheet tape-like substructure.
1. A method of treating and/or alleviating dental caries, comprising:
contacting a composition comprising a peptide P11-4 (SEQ ID NO: 1) to an affected tooth surface, thereby treating the caries.
2. The method of claim 1 , wherein the peptide P11-4 (SEQ ID NO: 1) forms or is present as a gel at a physiological pH.
3. The method of claim 1 , wherein the peptide P11-4 (SEQ ID NO: 1) forms or is present as ribbons, fibrils or fibres at a physiological pH.
4. The method of claim 1 , wherein the peptide P11-4 (SEQ ID NO: 1) is conjugated to a bioactive peptide.
5. The method according to claim 1 , wherein the peptide P11-4 (SEQ ID NO: 1) is conjugated to a therapeutically active molecule.
6. A method of promoting mineralisation or remineralisation of dental tissue, comprising:
contacting a composition comprising a peptide P11-4 (SEQ ID NO: 1) to a dental tissue to be treated, thereby promoting mineralisation or remineralisation of the dental tissue.
7. The method of claim 6 , wherein the peptide P11-4 (SEQ ID NO: 1) forms or is present as a gel at a physiological pH.
8. The method of claim 6 , wherein the peptide P11-4 (SEQ ID NO: 1) forms or is present as ribbons, fibrils or fibres at a physiological pH.
9. The method of claim 6 , wherein the peptide P11-4 (SEQ ID NO: 1) is conjugated to a bioactive peptide.
10. The method of claim 6 , wherein the peptide P11-4 (SEQ ID NO: 1) is conjugated to a therapeutically active molecule.
11. A method of decreasing or suppressing demineralisation of dental tissue, comprising:
contacting a composition comprising a peptide P11-4 (SEQ ID NO: 1) to a dental tissue. to be treated, thereby decreasing or suppressing demineralisation of the dental tissue.
12. The method of claim 11 , wherein the peptide P11-4 (SEQ ID NO: 1) forms or is present as a gel at a physiological pH.
13. The method of claim 11 , wherein the peptide P11-4 (SEQ ID NO: 1) forms or is present as ribbons, fibrils or fibres at a physiological pH.
14. The method of claim 11 , wherein the peptide P11-4 (SEQ ID NO: 1) is conjugated to a bioactive peptide.
15. The method of claim 11 , wherein the peptide P11-4 (SEQ ID NO: 1) is conjugated to a therapeutically active molecule.
16. A method of treating and/or alleviating dental hypersensitivity, comprising:
contacting a composition comprising a peptide P11-4 (SEQ ID NO: 1) to a dental tissue to be treated, thereby treating and/or alleviating dental hypersensitivity of the dental tissue.
17. The method of claim 16 , wherein the peptide P11-4 (SEQ ID NO: 1) forms a gel or is present as a gel at a physiological pH.
18. The method of claim 16 , wherein the peptide P11-4 (SEQ ID NO: 1) forms or is present as ribbons, fibrils or fibres at a physiological pH.
19. The method of claim 16 , wherein the peptide P11-4 (SEQ ID NO: 1) is conjugated to a bioactive peptide.
20. The method of claim 16 , wherein the peptide P11-4 (SEQ ID NO: 1) is conjugated to a therapeutically active molecule.