IP Library › Patent Application 14195834
Patent Application
App. No. 14/195,834

PLATFORM OF DENDRITIC CELL (DC)-BASED VACCINATION

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Patent No.
US None
App. No.
14/195,834
Abstract

The present invention discloses novel dendritic cell maturation-inducing cytokine cocktails, and methods for inducting type-1 polarized dendritic cells in serum-free conditions which enhance the desirable properties of DC1s generated in serum-supplemented cultures. The invention further discloses methods and systems using IFNγ and other ligands of the IFNγ receptor, in combination with IFNα (or other type I interferons), poly I:C, and other IFNα (and IFNβ) inducers to enhance the IL-12-producing properties of dendritic cells. More specifically, the present invention discloses type-1 polarized dendritic cells that have a unique combination of a fully-mature status and an elevated, instead of “exhausted”, ability to produce IL-12p70. allows for the generation of fully-mature DC1s in serum-free AIM-V medium. The invention discloses systems that use the foregoing products and methods to facilitate the clinical application of DC1-based vaccines and the identification of novel factors involved in the induction of Th1 and CTL responses by DC1.

Claims (3)

1 . A population of cells wherein

a. said cells are antigen-presenting; and

b. said cells are activated or matured by a combination of type I interferons, or analogs or inducers of said type I interferons, and type II interferons or analogs of said type II interferons.