2-Aminopyridine-based selective neuronal nitric oxide synthase inhibitors
Aminopyridine compounds, as can be used in conjunction with methods for modulation of nitric oxide synthase activity.
1. A compound selected from compounds of a formula
wherein R 1 is selected from 6-aminopyridin-2-yl, 6-amino-4-methylpyridin-2-yl, phenyl, fluorophenyl and chlorophenyl moieties; R 2 is selected from H, methyl and ethyl moieties; and L is selected from CH 2 O, CH 2 CH 2 , CH 2 N, CH 2 O(CH 2 ) 2 O, (CH 2 ) 5 and CH 2 N(CH 2 ) 2 N moieties, and salts thereof.
2. The compound of claim 1 wherein R 1 is selected from 6-amino-4-methylpyridin-2-yl and fluorophenyl moieties.
3. The compound of claim 2 wherein L is selected from CH 2 O and CH 2 O(CH 2 ) 2 O moieties.
4. The compound of claim 3 wherein R 2 is H.
5. The compound of claim 3 selected from cis and trans diastereomers.
6. The compound of claim 1 wherein said compound is an ammonium salt.
7. The compound of claim 5 wherein said ammonium salt has a counter ion that is a conjugate base of a protic acid.