Opioid antagonists
View Patent ↗Certain quinolizidine and octahydropyridopyrazine compounds, pharmaceutical compositions, and methods of their use, inter alia, as opioid receptor antagonists are disclosed.
1. A compound of formula I:
wherein:
R 1 is —C(═O)NH 2 ;
X is N—C(═O)-aryl;
or a pharmaceutically acceptable salt thereof.
2. The compound of claim 1 , wherein said aryl is substituted with halo.
3. The compound of claim 2 , wherein said aryl is substituted with fluoro.
4. A method for binding delta opioid receptors, comprising the step of contacting one or more delta opioid receptors with a compound of formula (I) or a salt thereof in an amount effective to bind to the opioid receptor,
wherein:
R 1 is —C(═O)NH 2 ;
X is N—C(═O)-aryl;
or a pharmaceutically acceptable salt thereof.
5. The method of claim 4 , wherein said aryl is substituted with halo.
6. The method of claim 5 , wherein said aryl is substituted with fluoro.