Sodium containing sol-gel derived bioactive glasses and uses thereof including hemostasis
A sol-gel bioactive glass precursor, method for making sol-gel glasses, resultant sol-gel bioactive glasses, and methods of use thereof which include introducing Na 2 O into the glass network during the sol-gel process through the use of Na-ethoxide, NaCl, or sodium silicate rather than sodium nitrate. Medical and industrial uses of such glasses.
1. A sol-gel bioactive glass comprising Si, Ca, P, and Na, wherein the sol-gel bioactive glass is derived from a mixture including a sodium source selected from the group consisting of NaCl and C 2 H 5 ONa, the sol-gel bioactive glass having a porous structure and a significantly higher specific surface area as compared to a melt-derived bioactive glass of the same composition, wherein the sol-gel bioactive glass is strontium free, wherein the significantly higher specific surface area is at least 30 times higher than the melt-derived bioactive glass specific surface area.
2. The sol-gel bioactive glass of claim 1 , wherein the Na source is NaCl.
3. The sol-gel bioactive glass of claim 1 , wherein the Na source is C 2 H 5 ONa.
4. The sol-gel bioactive glass of claim 1 , wherein the bioactive sol-gel glass is in a granular form, particulate form, matt form, fiber form, hemostatic sponge form, foam form, paste or putty form, or sphere or bead form, or a combination thereof.
5. A method of making mthe sol-gel bioactive glass of claim 1 including Si, Ca, P, and Na comprising:
mixing a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is selected from the group consisting of NaCl and C 2 H 5 ONa;
aging the mixture, and
drying the mixture to form the sol-gel bioactive glass.
6. The method of claim 5 , wherein said aging is conducted at a temperature of 50-80° C. for 40-70 hours.
7. The method of claim 5 , further comprising sintering at 500-900° C. for 15 to 50 hours.
8. A method for achieving hemostasis in a patient in need of treatment thereof comprising contacting the patient with the sol-gel bioactive glass of claim 1 .
9. A method of inducing rapid coagulation in a bleeding patient comprising contacting the patient with the sol-gel bioactive glass of claim 1 .
10. The sol-gel bioactive glass of claim 1 , wherein Si, Ca, P, and Na are present in their oxide form of SiO 2 , CaO, P 2 O 5 , and Na 2 O.
11. The sol-gel bioactive glass of claim 10 , further comprising one or more of K, Mg, Zn, B, F, or Ag.
12. A method of making the sol-gel bioactive glass of claim 1 including Si, Ca, P, and Na comprising:
mixing a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na, wherein the sodium source is selected from the group consisting of NaCl and C 2 H 5 ONa, and
drying the mixture at a temperature of 100° C. or lower.
13. The method of claim 12 , further comprising adding a biologically active molecule.
14. A method of treating wounds in a patient comprising contacting the patient with the sol-gel bioactive glass of claim 1 .
15. A method of repairing bone in a patient comprising contacting the bone in need of treatment with the sol-gel bioactive glass of claim 1 .
16. A sol-gel bioactive glass comprising Si, an alkaline earth metal, P, and alkali metal, wherein the sol-gel bioactive glass is derived from a mixture including a sodium source other than sodium nitrate, the sodium source selected from organosodium containing compound or an inorganic sodium salt, the sol-gel bioactive glass having a porous structure and a significantly higher specific surface area as compared to a melt-derived bioactive glass of the same composition, wherein the sol-gel bioactive glass is strontium free, wherein the significantly higher specific surface area is at least 30 times higher than the melt-derived bioactive glass specific surface area.
17. A method for achieving hemostasis in a patient in need of treatment thereof comprising contacting the patient with the sol-gel bioactive glass of claim 16 comprising Si, Ca, P, and Na, wherein the sol-gel bioactive glass is derived from a mixture including a sodium source, wherein the sodium source is sodium silicate.
18. A method of making the sol-gel bioactive glass of claim 16 including Si, Ca, P, and Na comprising:
mixing a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na,
wherein the sodium source is sodium silicate;
aging the mixture, and
drying the mixture to form the sol-gel bioactive glass.
19. The sol-gel bioactive glass of claim 1 , wherein the mixture further includes a sol-gel bioactive glass precursor including a source of Si, Ca, P, and Na.
20. The sol-gel bioglass of claim 19 , wherein the Si source is tetraethoxysilane.
21. The sol-gel bioglass of claim 19 , wherein the Ca source is calcium nitrate tetra-hydrate.
22. The sol-gel bioglass of claim 19 , wherein the Ca source is calcium methoxide.
23. The sol-gel bioglass of claim 19 , wherein the P source is triethylphosphate or sodium hexametaphosphate.
24. The sol-gel bioglass of claim 19 , wherein the Na source is NaCl.
25. The sol-gel bioglass of claim 19 , wherein the source of Na is C 2 H 5 ONa and the sol-gel bioactive glass precursor is present in an amount to provide for 20-30% by weight of Na 2 O in a sol-gel bioactive glass.
26. The sol-gel bioglass of claim 19 , wherein the source of Na is NaCl and the sol-gel bioactive glass precursor is present in an amount to provide for 20-30% by weight of Na 2 O in a sol-gel bioactive glass.
27. The sol-gel bioglass of claim 19 , wherein the Na source is C 2 H 5 ONa.
28. The sol-gel bioglass of claim 19 , wherein the source of phosphorus is triethylphosphate and the sol-gel bioactive glass precursor is present in an amount to provide for 20-30% by weight of P 2 O 5 in a sol-gel bioactive glass.
29. The sol-gel bioglass of claim 1 , wherein the mixture further comprises a sol-gel bioactive glass precursor including a source of Si, Ca, and Na, wherein the sodium source is selected from the group consisting of NaCl and C 2 H 5 ONa.