IP Library › Granted Patent US 8,835,630
Granted Patent B1
US 8,835,630 · App. 14/211,235 · Granted Sep 16, 2014

Acyclic nucleoside phosphonate diesters

Inventors: Karl Y. Hostetler (Del Mar, CA); James R. Beadle (San Diego, CA); Nadejda Valiaeva (San Diego, CA)
Assignee: The Regents of the University of California, a California corporation
C07F9/65616C07F9/65121
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Quick Facts
Patent No.
US 8,835,630
App. No.
14/211,235
Granted
Sep 16, 2014
Kind
B1
Abstract

The present disclosure relates, inter alia, to compositions and methods for treating viral diseases and cancer. There are disclosed lipophilic antiviral and anticancer acyclic nucleoside phosphonate diesters, preparation thereof, and methods of using the compounds to treat viral diseases and cancer.

Claims (42)

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt of any of the foregoing.

2. The compound of claim 1 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

3. The compound of claim 2 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

4. The compound of claim 2 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

5. The compound of claim 1 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

6. The compound of claim 5 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

7. The compound of claim 5 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

8. The compound of claim 1 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

9. The compound of claim 8 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

10. The compound of claim 9 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

11. The compound of claim 9 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

12. The compound of claim 8 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

13. The compound of claim 12 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

14. The compound of claim 12 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

15. The compound of claim 1 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

16. The compound of claim 15 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

17. The compound of claim 16 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

18. The compound of claim 16 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

19. The compound of claim 15 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

20. The compound of claim 19 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

21. The compound of claim 19 , wherein the compound is:

or a pharmaceutically acceptable salt thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 7, 2014
From: HOSTETLER, KARL Y.; BEADLE, JAMES R.; VALIAEVA, NADEJDA
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION
Reel/Frame 033491/0234 →
Continuity (1)
Provisional Application 61793993 · Mar 15, 2013