Diarylhydantoin compounds
View Patent ↗The present invention relates to diarylhydantoin compounds and methods for synthesizing them and using them in the treatment of hormone refractory prostate cancer.
1. A method for treating prostate cancer or breast cancer comprising administering a compound to a subject in need of such treatment, thereby treating the prostate cancer or breast cancer,
wherein the compound is of formula
wherein R 1 and R 2 together comprise eight or fewer carbon atoms and are alkyl, or are substituted alkyl, or, together with the carbon to which they are linked, form a cycloalkyl or substituted cycloalkyl group,
wherein R 4 is selected from the group consisting of hydrogen, F, Cl, Br, and I,
wherein R 11 and R 12 are independently selected from the group consisting of hydrogen and methyl,
wherein R 3 is selected from the group consisting of formyl,
provided that when R 4 , R 11 , and R 12 are all hydrogen and when R 1 and R 2 together with the carbon to which they are linked are cyclobutyl, then R 3 is not formyl, or
a pharmaceutically acceptable salt thereof.
2. The method of claim 1 ,
wherein R3 of the compound is selected from the group consisting of
3. The method of claim 1 , wherein the compound is of formula
wherein R21 is selected from the group consisting of
or
a pharmaceutically acceptable salt thereof.
4. The method of claim 1 , wherein the compound is administered as a pharmaceutical composition comprising the compound and a pharmaceutically acceptable carrier or diluent.
5. The method of claim 1 , wherein the compound is administered at a dosage of the compound in the range of from about 0.001 mg per kg body weight per day to about 100 mg per kg body weight per day.
6. The method of claim 1 , wherein the compound is administered at a dosage of the compound in the range of from about 0.01 mg per kg body weight per day to about 100 mg per kg body weight per day.
7. The method of claim 1 , wherein the compound is administered at a dosage of the compound in the range of from about 0.1 mg per kg body weight per day to about 10 mg per kg body weight per day.
8. The method of claim 1 , wherein the compound is administered at a dosage of the compound of about 1 mg per kg body weight per day.
9. The method of claim 1 , for treating hormone refractory prostate cancer.
10. The method of claim 1 , wherein the compound is administered by intravenous injection, by injection into tissue, intraperitoneally, orally, or nasally.
11. The method of claim 1 , wherein the compound is administered orally.
12. The method of claim 4 , wherein the pharmaceutical composition has a form selected from the group consisting of a solution, dispersion, suspension, powder, capsule, tablet, pill, time release capsule, time release tablet, and time release pill.
13. The method of claim 4 , wherein the pharmaceutical composition has a form selected from the group consisting of a capsule, tablet, and pill.
14. The method of claim 1 , wherein the compound is of formula
or
a pharmaceutically acceptable salt thereof.
15. The method of claim 1 , wherein the compound is of formula
or
a pharmaceutically acceptable salt thereof.
16. The method of claim 1 , wherein the compound is of formula
or
a pharmaceutically acceptable salt thereof.
17. The method of claim 1 , for treating hormone sensitive prostate cancer.
18. The method of claim 1 , for treating breast cancer.
19. The method of claim 9 , wherein the compound is of formula
or
a pharmaceutically acceptable salt thereof.
20. The method of claim 9 , wherein the compound is of formula
or
a pharmaceutically acceptable salt thereof.
21. The method of claim 9 , wherein the compound is of formula
or
a pharmaceutically acceptable salt thereof.