Compositions and methods for treating neoplastic diseases
Disclosed herein are compositions and methods for treating neoplastic diseases. Included are compositions and methods that are effective against multiple myeloma cells resistant to conventional and bortezomib treatment. Furthermore, combination treatment with two different proteosome inhibitors is shown to be synergistic for treating multiple myeloma.
1. A method of treating a neoplastic disease, comprising administering to a patient inflicted with the neoplastic disease: bortezomib; and
a compound of formula (I) or a pharmaceutically acceptable salt thereof:
wherein X is selected from the group consisting of fluorine, chlorine, bromine or iodine;
wherein the neoplastic disease is multiple myeloma; and
wherein the neoplastic disease is sensitive to bortezomib.
2. The method of claim 1 , wherein X is chlorine.
3. The method of claim 1 , wherein the compound of formula (1) has the structure of formula (II):
4. The method of claim 1 , wherein the patient is a human.