Methods for treating inflammation and hypertension with γ-ketoaldehyde skavengers
A method of treating at least one of inflammation, psoriasis, and/or hypertension comprising administering to a patient in need there of an effective gamma-ketoaldehyde scavenging amount of a gamma-ketoaldehyde scavenging compound.
1. A method of treating or ameliorating an isoprostane induced inflammatory autoimmune response, comprising administering a gamma-ketoaldehyde scavenging effective amount to a patient in need thereof a compound of the following formula:
and stereoisomers and pharmaceutically acceptable salts thereof,
wherein the inflammatory autoimmune response includes at least one of hypertension, psoriasis, or edema.
2. A method of treating hypertension, comprising administering to a patient in need thereof an effective amount of a compound of the following formula:
and stereoisomers and pharmaceutically acceptable salts thereof.
3. A method of treating hypertension, comprising co-administering to a patient in need thereof a gamma-ketoaldehyde scavenging effective amount of a compound of the following formula:
and stereoisomers and pharmaceutically acceptable salts thereof, with an additional pharmaceutical agent known for at least one of treating inflammation, treating an isoprostane-induced autoimmune response, and reducing hypertension.
4. The method of claim 1 , wherein the co-administration is separate compositions given at the same time or at different times.
5. A method of treating psoriasis, comprising administering to a patient in need thereof an effective amount of a compound of the following formula:
and stereoisomers and pharmaceutically acceptable salts thereof.