HCV IMMUNOTHERAPY
The invention relates to the use of Interleukin-7 (IL-7), for treating hepatitis C in a patient infected with hepatitis C virus, wherein said patient has been treated or is being treated with an antiviral agent or a combination of antiviral agents that reduces viral load.
1 - 15 . (canceled)
16 . A method for treating hepatitis C in a patient infected with hepatitis C virus comprising administering to said patient Interleukin-7 (IL-7), sequentially with, in combination with or subsequent to, an antiviral agent or a combination of antiviral agents.
17 . The method according to claim 16 , wherein the antiviral agent or combination of antiviral agents is administered in a therapeutically effective amount that reduces HCV viral load to less than 5 Log 10 IU/mL.
18 . The method according to claim 17 , wherein the patient has been treated with an antiviral agent or a combination of antiviral agents, so as to reduce viral load, before administration with IL-7.
19 . The method according to claim 16 , wherein the antiviral agent is selected from the group consisting of a protease inhibitor, a polymerase inhibitor, an inhibitor of virus entry, and a helicase inhibitor, or combinations thereof, optionally in combination with interferon and/or ribavirin.
20 . The method according to claim 16 , wherein the antiviral agent is an interferon, either alone or in combination with another antiviral agent and wherein the interferon is optionally PEGylated.
21 . The method according to claim 16 , wherein the treatment with the antiviral agent or the combination of antiviral agents is started simultaneously with the treatment with IL-7, and maintained during at least part of the treatment with IL-7.
22 . The method according to claim 16 , wherein the treatment with the antiviral agent or the combination of antiviral agents is started before the treatment with IL-7, and maintained during at least part of the treatment with IL-7.
23 . The method according to claim 16 , wherein IL-7 is administered once a week during a period of two to six weeks (a treatment cycle) and said treatment cycle is optionally repeated at least once.
24 . The method according to claim 16 , wherein IL-7 is to be administered separately, simultaneously or sequentially with the antiviral agent or combination of antiviral agents, and wherein the IL-7 treatment is started before the administration of the antiviral agent or combination of antiviral agents.
25 . The method according to claim 16 , wherein an antiviral agent or a combination of antiviral agents is administered to the patient during a first phase of one week, so as to reduce the viral load, followed by a second phase of four weeks of IL-7 combined with an antiviral agent or a combination of antiviral agents, wherein the antiviral agent or combination of antiviral agents may be the same or different during all treatment phases.
26 . The method according to claim 25 , wherein the administration of IL-7 is followed by a third phase of 1 to 9 weeks of treatment with an antiviral agent or a combination of antiviral agents, wherein the antiviral agent or combination of antiviral agents is the same or different during all treatment phases.
27 . The method according to claim 16 , wherein the patient has chronic hepatitis C genotype 1 to 6 infection.
28 . The method according to claim 16 , wherein said treatment provides HCV viral clearance, prevents or delays onset of liver fibrosis and cirrhosis, and/or prevents relapse of HCV infection.
29 . The method according to claim 16 , wherein the IL-7 is in the form of a fusion protein.
30 . The method according to claim 16 , wherein the IL-7 is a wild-type human IL-7 or a variant thereof.
31 . The method according to claim 30 , wherein said IL-7 variant is hyperglycosylated.