IP Library › Granted Patent US 9,676,870
Granted Patent B2
US 9,676,870 · App. 14/236,544 · Granted Jun 13, 2017

Methods of treating atherosclerosis and aneurysm

Inventor: Guo-Ping Shi (Newton, MA)
Assignee: The Brigham and Women's Hospital, Inc.
C07K16/4291A61K2039/505
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Quick Facts
Patent No.
US 9,676,870
App. No.
14/236,544
Granted
Jun 13, 2017
Kind
B2
Abstract

The technology described herein is directed to methods of treating cardiovascular and metabolic disorders.

Claims (4)

1. A method comprising, administering a therapeutically effective amount of an IgE signaling inhibitor to a subject in need of a treatment for atherosclerosis, wherein the IgE inhibitor binds to IgE and inhibits the binding of IgE to a receptor molecule.

2. A method comprising, administering a therapeutically effective amount of an IgE signaling inhibitor to a subject in need of a treatment for abdominal aortic aneurysm, wherein the IgE inhibitor binds to IgE and inhibits the binding of IgE to a receptor molecule.

3. The method of claim 1 , wherein the IgE inhibitor is selected from the group consisting of; an IgE monoclonal antibody; omalizumab; and talizumab.

4. The method of claim 2 , wherein the IgE inhibitor is selected from the group consisting of; an anti-IgE monoclonal antibody; omalizumab; and talizumab.

Assignments (1)
CONFIRMATORY LICENSE Recorded Aug 28, 2015
From: BRIGHAM AND WOMEN'S HOSPITAL
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 036504/0962 →
Continuity (2)
Provisional Application 61514992 · Aug 4, 2011
Related Publication 20140322199A1 · Oct 30, 2014