IP Library › Granted Patent US 9,243,234
Granted Patent B2
US 9,243,234 · App. 14/236,947 · Granted Jan 26, 2016

Sequence-specific MRNA interferase and uses thereof

Inventors: Masayori Inouye (New Brunswick, NJ); Yoshihiro Yamaguchi (Somerset, NJ)
Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
C12N9/22C12Q1/6869
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Quick Facts
Patent No.
US 9,243,234
App. No.
14/236,947
Granted
Jan 26, 2016
Kind
B2
Abstract

The present invention provides an improved and specific mRNA interferase and related methods of protein-based mRNA interference.

Claims (7)

1. An isolated polypeptide comprising an amino acid sequence that is at least 95% identical to the sequence of SEQ ID NO: 1.

2. The polypeptide of claim 1 , having an mRNA interferase activity.

3. The polypeptide of claim 1 , wherein the amino acid sequence is at least 99% identical to the sequence of SEQ ID NO: 1.

4. The polypeptide of claim 3 , wherein the amino acid sequence comprises the sequence of SEQ ID NO: 1.

5. The polypeptide of claim 1 , wherein the polypeptide has an activity of cleaving an RNA sequence having the target sequence of UUACUCA.

6. A composition comprising the polypeptide of claim 1 and a carrier.

7. A kit comprising the polypeptide of claim 1 and a buffer.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 8, 2022
From: RUTGERS, THE STATE UNIV. OF N.J.
To: NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR
Reel/Frame 059198/0279 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 7, 2014
From: INOUYE, MASAYORI; YAMAGUCHI, YOSHIHIRO
To: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
Reel/Frame 032379/0942 →
Continuity (2)
Provisional Application 61515049 · Aug 4, 2011
Related Publication 20140294801A1 · Oct 2, 2014