Treatment of sleep disorders
The use of 7-chloro-3-(5-dimethylaminomethyl-[1,2,4]oxadiazol-3-yl)-5methyl-4,5-dihydro-imidazol[1,5,-a][1,4]benzodiazepine-6-one or its pharmaceutically acceptable salt for treating various types of insomnia.
1. A method for treating maintenance insomnia in a human in need thereof comprising administering to the human before bedtime an amount of a compound of formula (II) or a pharmaceutically acceptable salt thereof effective to treat the maintenance insomnia and to increase total sleep time in a period of about four to about eight hours after administration
2. The method according to claim 1 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 0.5 mg to about 5 mg.
3. The method according to claim 1 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 1 mg to about 3 mg.
4. The method according to claim 1 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 1.5 mg to about 2.5 mg.
5. The method according to claim 1 , wherein the human is at least 65 years old.
6. A method for treating terminal insomnia in a human in need thereof comprising administering to the human before bedtime an amount of a compound of formula (II) or a pharmaceutically acceptable salt thereof effective to treat the terminal insomnia and to increase total sleep time in a period of about four to about eight hours after administration
7. The method according to claim 6 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 0.5 mg to about 5 mg.
8. The method according to claim 6 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 1 mg to about 3 mg.
9. The method according to claim 6 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 1.5 mg to about 2.5 mg.
10. The method according to claim 6 , wherein the human is at least 65 years old.
11. The method according to claim 6 , which is also for treatment of maintenance insomnia, wherein the compound of formula (II) or the pharmaceutically acceptable salt thereof is administered to the human in need of treatment of the maintenance insomnia and the terminal insomnia.
12. A method for increasing total sleep time in a period in a human in need thereof comprising administering to the human before bedtime an amount of a compound of formula (II) or a pharmaceutically acceptable salt thereof effective to increase total sleep time in the period, which is about four to about eight hours after administration
13. The method according to claim 12 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 0.5 mg to about 5 mg.
14. The method according to claim 12 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 1 mg to about 3 mg.
15. The method according to claim 12 , wherein the amount of the compound of formula (II) or the pharmaceutically acceptable salt thereof is from about 1.5 mg to about 2.5 mg.
16. The method according to claim 12 , wherein the human is at least 65 years old.
17. The method according to claim 12 , wherein the period is from about five to about eight hours after administration.
18. The method according to claim 12 , wherein the period is from about six to about eight hours after administration.