Methods of treating antinociceptive tolerance
The invention relates to methods for treating pain disorders including neuropathic and inflammatory pain and to methods to reduce or eliminate nociceptive tolerance induced by opiate analgesic use by administering an agent that suppresses or blocks S1P biological activity.
1. A method of treating opiate-induced antinociceptive tolerance in an individual, the method comprising administering to the individual an effective amount of a drug selected from S1P receptor agonists and S1P receptor antagonists.
2. The method of claim 1 , wherein the antinociceptive tolerance is induced by morphine.
3. The method of claim 1 , wherein the S1P receptor agonist is an agonist of S1P1.
4. The method of claim 1 , wherein the S1P receptor agonist is selected from the group consisting of Fingolimod, BAF312, ACT-128800, ONO-4641, CS-0777, KRP-203, PF-991, W146, and combinations thereof.