Enamel protectant and repair toothpaste treatments

1. An aqueous-free, enamel protectant and enamel repair, toothpaste treatments containing: stannous fluoride and calcium in a substantivity agent selected from emulsions of polymethylsiloxanes in nonionic poloxamer surfactants, wherein:

(a) Substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through a shift in calcium binding from bidentate to monodentate in the presence of stannous fluoride;

(b) EPF and ERF values of at least 2.5 and 200, respectively, are achieved with periodic administration of said toothpastes onto enamel surfaces with biofilm present;

(c) wherein the stannous fluoride is present in an amount of 400-1100 ppm;

(d) wherein the composition has a pH of 3-5.8;

(e) wherein the calcium content is 0.5-5.0%;

(f) wherein the calcium is limited to one or more of calcium fumarate, calcium sulfate, calcium gluconate, and mixed sodium and calcium salts of methyl/vinyl/ether/maleic copolymers thereof; and

(g) wherein said nonionic poloxamer is selected from solid and liquid, nonionic poloxamers and combinations thereof.

2. A treatment according to claim 1 , wherein some of said stannous fluoride and calcium is present as CaF + .

3. A treatment according to claim 1 , wherein said substantivity agent contains linear, polymeric polycarboxylate, substantivity enhancers.

4. Substantially aqueous-free, enamel protectant and enamel repair, toothpaste treatments according to claim 3 , containing stannous fluoride and calcium in a substantivity agent comprising an emulsion of polydimethylsiloxane polymer at viscosities from between about 10,000 cs and about 2.5 million cs as the discontinuous phase in a nonionic surfactant, continuous phase.

5. Toothpaste treatments, according to claim 4 , wherein nonionic poloxamer surfactants, suitable for said toothpastes, are represented by the structural formula:

HO[(C 2 H 4 O) x /(C 3 H 6 O) y ]—[C 3 H 6 O ] z —[(C 2 H 4 O) x /(C 3 H 6 O) y ]H

wherein the sum of x, y and z is from between 125 and 175.

6. Toothpaste treatments according to claim 3 , wherein nonionic surfactants, suitable for said toothpastes, are represented by the structural formula:

HO[(C 2 H 4 O) x /(C 3 H 6 O) y ]—[C 3 H 6 O ] z —[(C 2 H 4 O) x /(C 3 H 6 O) y ]H

wherein x =76, y =25 and z =56.

7. Toothpaste treatments, according claim 1 , containing unreacted, calcium and phosphate components.

8. An aqueous-free, enamel protectant and enamel repair, toothpaste treatments containing stannous fluoride and calcium in a substantivity agent comprising an emulsion of polydimethylsiloxane polymer at viscosities from between about 10,000 cs and about 2.5 million cs as the discontinuous phase in a nonionic poloxamer surfactant, continuous phase containing a linear polymeric polycarboxylates substantivity enhancers

wherein said nonionic surfactant is a surfactant selected from the group consisting of surfactants having the following, general, structural formula:

HO[(C 2 H 4 O) x /(C 3 H 6 O) y ]—[C 3 H 6 O] z —[(C 2 H 4 O) x /(C 3 H 6 O) y ]H

wherein the sum of x, y and z is from between 125 and 175; wherein:

(a) Substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through a shift in calcium binding from bidentate to monodentate in the presence of stannous fluoride;

(b) EPF and ERF values of at least 2.5 and 200, respectively, are achieved with periodic administration of said toothpastes onto enamel surfaces with biofilm present;

(c) wherein the stannous fluoride is present in an amount of 400-1100 ppm;

(d) wherein the composition has a pH of 3-5.8;

(e) wherein the calcium content is 0.5-5.0%;

(f) wherein the calcium is limited to one or more of calcium fumarate, calcium sulfate, calcium gluconate, and mixed sodium and calcium salts of methyl/vinyl/ether/maleic copolymers thereof; and

(g) wherein said nonionic poloxamer is selected from solid and liquid, nonionic poloxamers and combinations thereof.

9. Toothpaste treatments, according to claim 8 , wherein nonionic poloxamer surfactants, suitable for said toothpastes, are represented by the structural formula:

HO[(C 2 H 4 O) x /(C 3 H 6 O) y ]—[C 3 H 6 O ] z —[(C 2 H 4 O) x /(C 3 H 6 O) y ]H

wherein the sum of x, y and z is from between 125 and 150.

10. Toothpastes, according to claim 8 , wherein nonionic poloxamer surfactants, suitable for said toothpastes, are represented by the structural formula:

HO[(C 2 H 4 O) x /(C 3 H 6 O) y ]—[C 3 H 6 O ] z —[(C 2 H 4 O) x /(C 3 H 6 O) y ]H

wherein x =76, y =0 and z =56.

11. Toothpaste treatments, according claim 8 , containing unreacted, calcium and phosphate components.

12. An aqueous-free, enamel protectant and enamel repair, toothpaste treatments, featuring monodentate-bidentate bonding of calcium in the presence of stannous fluoride; containing: stannous fluoride, calcium and phosphate components, and a substantivity agent emulsion containing nonionic poloxamer surfactant as the continuous phase and polydimethylsiloxane polymer as the discontinuous phase; with an EPF of at least 2.5 and ERF of at least 200;

(a) wherein the stannous fluoride is present in an amount of 400-1100 ppm;

(b) wherein the composition has a pH of 3-5.8;

(c) wherein the calcium content is 0.5-5.0%;

(d) wherein the calcium is limited to one or more of calcium fumarate, calcium sulfate, calcium gluconate, and mixed sodium and calcium salts of methyl/vinyl/ether/maleic copolymers thereof; and

(e) wherein said nonionic poloxamer is selected from solid and liquid, nonionic poloxamers and combinations thereof.

13. Toothpaste treatments, according to claim 5 , wherein said polydimethylsiloxane polymer discontinuous phase comprises up to 20% of said emulsion.

14. An aqueous-free, enamel protectant and enamel repair, toothpaste treatments containing stable stannous fluoride and calcium on a substantivity agent selected from emulsions of polymethylsiloxanes in nonionic poloxamer surfactants, substantive to biofilm coated enamel, wherein:

(a) substantivity of said stannous fluoride and calcium into said biofilm is enhanced by a substantivity enhancer and by a shift from bidentate binding of calcium to monodentate in the presence of stable stannous fluoride;

(b) said stannous fluoride, upon release from said substantivity agent, converts to the moiety CaF + which effects EPF and ERF values of at least 2.5 and about 200, respectively;

(c) wherein the stannous fluoride is present in an amount of 400-1100 ppm;

(d) wherein the composition has a pH of 3-5.8;

(e) wherein the calcium content is 0.5-5.0%;

(f) wherein the calcium is limited to one or more of calcium fumarate, calcium sulfate, calcium gluconate, and mixed sodium and calcium salts of methyl/vinyl/ether/maleic copolymers thereof; and

(g) wherein said nonionic poloxamer is selected from solid and liquid, nonionic poloxamers and combinations thereof.

15. Toothpaste treatments, according to claim 1 , wherein said stannous fluoride, upon release from said substantivity agent, includes a CaF + moiety in the presence of said calcium monodentate binding to said biofilm present on enamel.

16. Toothpaste treatments, according to claim 1 , wherein the pH of said toothpastes, upon administration to enamel with biofilm, is about 3.

17. Toothpaste treatments, according to claim 3 , wherein the level of said substantivity agent and said substantivity enhancers is between about 0.5 and about 5% by wt. and about 0.1 and about 3% by wt., respectively.

18. Toothpaste treatments, according to claim 3 , wherein said substantivity enhancer has the structural formula:

where m is an integer that provides weight between about 60,000 and about 1,000,000.

19. Toothpaste treatments, according to claim 8 , wherein the concentration of polydimethylsiloxane is up to about 20% by wt. of said emulsion.

20. Toothpaste treatments, according to claim 14 , wherein: the ratio of unreacted calcium and phosphate components is from between about 2 and about 1, and the level of calcium and phosphate mixture in said toothpastes ranges from between about 0.2% and about 3%.

21. Toothpaste treatments, according to claim 14 , wherein: the pH of said toothpaste, upon exposure to saliva, is from between about 4 and about 8.