Systems and methods for treating pancreatic cancer

1. A method of treating pancreatic cancer in a patient, comprising:

inserting a device into a stomach or a duodenum, wherein the device comprises a first elongated member with a lumen, and a second elongated member disposed within the lumen of the first elongated member, the second elongated member comprising a transducer for providing ultrasonic energy;

securing at least a portion of the device in position relative to the stomach or the duodenum, wherein the at least a portion of the device comprises an expandable member, and the act of securing the at least a portion of the device comprises expanding the expanding member to engage at least two opposite walls of the stomach or the duodenum;

moving the second elongated member relative to the first elongated member, wherein the act of moving the second elongated member comprises translating the second elongated member relative to the first elongated member;

inserting the transducer through a wall of the stomach or through a wall of the duodenum into a pancreas; and

delivering the ultrasonic energy from the transducer to treat a target site in the pancreas;

wherein the ultrasonic energy is delivered from within the pancreas to directly interact with tissue in the pancreas to cause a change at a cellular level of the tissue;

wherein the transducer comprises a plurality of transducer elements that are arranged at the second elongated member, wherein the act of delivering the ultrasonic energy comprises activating at least one of the plurality of the transducer elements that aligns with the target site to deliver the ultrasonic energy to the target site in the pancreas, while one or more other ones of the transducer elements not aligned with the target site are un-activated, the at least one of the plurality of the transducer elements constitute a subset, and not all, of the transducer elements.

2. The method of claim 1 , wherein the ultrasonic energy is delivered from the device to create heat, hyperthermia, or thermal ablation, at the target site.

3. The method of claim 1 , the ultrasonic energy is delivered to create mechanical perturbations at the target site in the pancreas.

4. A method of treating pancreatic cancer in a patient, comprising:

inserting a device into a stomach or a duodenum;

securing at least a portion of the device in position relative to the stomach or the duodenum; and

delivering ultrasonic energy from the device to treat a target site in a pancreas;

wherein the at least a portion of the device comprises an expandable member, and the act of securing the at least a portion of the device comprises expanding the expanding member to engage at least two opposite walls of the stomach or the duodenum;

wherein the device further comprises a first elongated member with a lumen, and a second elongated member disposed within the lumen of the first elongated member, the second elongated member comprising an energy source for providing the ultrasonic energy to treat the target site, wherein the first elongated member is configured to house the expandable member, and wherein the method further comprises moving the second elongated member relative to the first elongated member, wherein the act of moving the second elongated member comprises translating the second elongated member relative to the first elongated member; and

wherein the energy source comprises a plurality of transducer elements that are arranged at the second elongated member, wherein the act of delivering the ultrasonic energy comprises activating at least one of the plurality of the transducer elements that aligns with the target site to deliver the ultrasonic enemy to the target site in the pancreas, while one or more other ones of the transducer elements not aligned with the target site are un-activated, the at least one of the plurality of the transducer elements constitute a subset, and not all, of the transducer elements.

5. The method of claim 4 , wherein the ultrasonic energy is delivered through a wall of the stomach or through a wall of the duodenum.

6. The method of claim 4 , wherein the expandable member comprises a stomach balloon or a duodenum balloon.

7. The method of claim 4 , wherein the expandable member comprises a balloon, and the ultrasonic energy is delivered through the balloon.

8. The method of claim 4 , wherein the device further comprises a balloon outside the expandable member.

9. The method of claim 4 , further comprising monitoring a thermal therapy process for the target site using a sensor that senses a characteristic of the target site.

10. A device for treating pancreatic cancer in a patient, comprising:

a first elongated member with a lumen, the first elongated member configured for insertion into a stomach or a duodenum;

a second elongated member disposed within the lumen of the first elongated member, the second elongated member comprising an energy source for providing ultrasonic energy, and an expandable member, the expandable member being a stomach balloon configured to secure at least a portion of the device relative to the stomach, or a duodenum balloon configured to secure the at least a portion of the device relative to the duodenum;

wherein the second elongated member has an exterior portion for contacting tissue, and is configured for translation and/or rotation relative to the first elongated member;

wherein the energy source is configured to deliver the ultrasonic energy to treat a target site in the pancreas; and

wherein the energy source comprises a plurality of transducer elements that are arranged at the second elongated member, wherein the second elongated member is moveable to align one or more of the transducer elements with the target site, and wherein at least one of the plurality of the transducer elements that aligns with the target site is configured to deliver the ultrasonic energy to the target site in the pancreas, while one or more other ones of the transducer elements not aligned with the target site are configured to be un-activated, the at least one of the plurality of the transducer elements constitute a subset, and not all, of the transducer elements.

11. The device of claim 10 , wherein the transducer elements are along a longitudinal axis of the device.

12. The device of claim 10 , wherein the transducer elements are along a circumference of the device.

13. The device of claim 10 , further comprising a user interface that allows a user to selectively activate one or more of the transducer elements, and/or to adjust an amount of energy being delivered by the one or more of the transducer elements.

14. A device for treating pancreatic cancer, comprising:

a first elongated member with a lumen, the first elongated member configured for insertion into a stomach or a duodenum;

an expandable member coupled to the first elongated member, wherein the expandable member is configured to engage at least two opposite walls of a stomach to secure at least a portion of the device relative to the stomach, or to engage at least two opposite walls of a duodenum to secure the at least a portion of the device relative to the duodenum, when in an expanded configuration;

a second elongated member disposed within the lumen of the first elongated member, wherein the second elongated member is configured to translate relative to the first elongated member; and

an energy source coupled to the second elongated member, the energy source configured to provide ultrasonic energy to treat a target site at a pancreas;

wherein the second elongated member has a distal end configured to exit from within the lumen of the first elongated member radially away from a longitudinal axis of the first elongated member; and

wherein the energy source comprises a plurality of transducer elements that are arranged at the second elongated member, wherein the second elongated member is moveable to align one or more of the transducer elements with the target site, and wherein at least one of the plurality of the transducer elements that aligns with the target site is configured to deliver the ultrasonic energy to the target site in the pancreas, while one or more other ones of the transducer elements not aligned with the target site are configured to be un-activated, the at least one of the plurality of the transducer elements constitute a subset, and not all, of the transducer elements.

15. The device of claim 14 , further comprising a monitoring device configured to monitor a treatment progress while the energy source delivers the ultrasonic energy, the monitoring device comprising a sensor.

16. The device of claim 14 , wherein the expandable member is distal to the first elongated member.

17. The device of claim 14 , wherein the distal end of the second elongated member is configured to pierce into tissue at the target site.