Granted Patent
B2
US 9,409,921 · App. 14/253,903 · Granted Aug 9, 2016
2,4-disubstituted pyrimidines as kinase inhibitors
Inventors:
Juswinder Singh (Ashland, MA); Russell Petter (Stow, MA); Richland Wayne Tester (Marlborough, MA); Arthur F. Kluge (Lincoln, MA); Hormoz Mazdiyasni (Marlborough, MA); William Frederick Westlin, III (Boxborough, MA); Deqiang Niu (Lexington, MA); Lixin Qiao (Tewksbury, MA)
Assignee:
Celgene Avilomics Research, Inc.
C07D495/04A61K31/505A61K31/506A61K31/519A61K31/538A61K31/5377A61K31/541A61K45/06C07D239/47C07D239/48C07D401/12C07D401/14C07D403/12C07D405/12C07D405/14C07D407/12C07D413/12C07D413/14C07D471/04C07D487/04C07D487/08C07D487/18
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Abstract
The present invention provides 2,4-disubstituted pyrimidine compounds useful as kinase inhibitors, pharmaceutically acceptable compositions thereof, and methods of using the same.
Claims (3)
1. A composition comprising a compound selected from the group consisting of:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable adjuvant, carrier, or vehicle in combination with an additional therapeutic agent.
2. The composition according to claim 1 , wherein the additional therapeutic agent is a chemotherapeutic agent.
Assignments (3)
NUNC PRO TUNC ASSIGNMENT
Recorded May 3, 2023
From: CELGENE CAR LLC
To: BRISTOL-MYERS SQUIBB COMPANY
Reel/Frame 063526/0959 →
MERGER AND CHANGE OF NAME
Recorded Feb 16, 2017
From: CELGENE AVILOMICS RESEARCH, INC.; CELGENE CAR LLC
To: CELGENE CAR LLC
Reel/Frame 041738/0041 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 7, 2014
From: SINGH, JUSWINDER; PETTER, RUSSELL; TESTER, RICHLAND WAYNE; KLUGE, ARTHUR F.; MAZDIYASNI, HORMOZ; WESTLIN, WILLIAM FREDERICK, III; NIU, DEQIANG; QIAO, LIXIN
To: CELGENE AVILOMICS RESEARCH, INC.
Reel/Frame 032840/0233 →
Continuity (7)
Provisional Application
61170874
· Apr 20, 2009
Provisional Application
61148388
· Jan 29, 2009
Provisional Application
61076450
· Jun 27, 2008