IP Library › Granted Patent US 9,913,879
Granted Patent B2
US 9,913,879 · App. 14/256,398 · Granted Mar 13, 2018

Methods for modulating an inflammatory response

Inventors: Christopher A. Hunter (Philadelphia, PA); Alejandro Villarino (Philadelphia, PA)
Assignee: The Trustees of the University of Pennsylvania
A61K38/20A61K38/208C07K16/2866A61K2039/505C07K2317/76
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Quick Facts
Patent No.
US 9,913,879
App. No.
14/256,398
Granted
Mar 13, 2018
Kind
B2
Abstract

The inventive subject matter relates to novel methods for modulating an immune response in an animal, which comprises administering to said animal an effective amount of an agent that increases IL-27R/WSX-1 activity. Further, the inventive subject matter relates to pharmaceutical compositions comprising an effective amount of an agent that increases IL-27R/WSX-1 activity.

Claims (3)

1. A method for increasing an immune response in a patient that has a suppressed immune system that is the result of a cancer or chemotherapy, the method comprising administering to said patient an effective amount of an IL-27R antagonist, wherein said antagonist is an antibody that binds to IL-27, an antibody that binds to EB13, an antibody that binds to IL27p28, or an antibody that binds to IL-27R, wherein any of said antibodies suppresses IL-27R activity in said patient.

2. The method of claim 1 , wherein said IL-27R antagonist prevents functional activation of IL-27R by IL27.

3. The method of claim 1 , wherein said patient is a human.

Assignments (1)
CONFIRMATORY LICENSE Recorded Jun 10, 2016
From: UNIVERSITY OF PENNSYLVANIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 038952/0920 →
Continuity (4)
Continuation 10768744 · Feb 2, 2004
Provisional Application 60444494 · Jan 31, 2003
Provisional Application 60519074 · Nov 10, 2003
Related Publication 20150079024A1 · Mar 19, 2015