Method of treatment of cardiovascular or renal conditions with natriuretic polypeptides with unique pharmacologic profiles
View Patent ↗This document provides natriuretic polypeptides. For example, this document provides polypeptides having a natriuretic activity. In some cases, a polypeptide provided herein can have natriuretic activities without inducing excessive hypotension. This document also provides methods and materials for inducing natriuretic activities within a mammal.
1. A method for treating a mammal having a cardiovascular condition or renal condition, wherein said method comprises administering, to said mammal, a composition comprising a polypeptide under conditions wherein the severity of a manifestation of said cardiovascular condition or renal condition is reduced, wherein said polypeptide is less than 44 amino acid residues in length and comprises, in an order from amino terminus to carboxy terminus:
(a) the sequence set forth in SEQ ID NO:6 or the sequence set forth in SEQ ID NO:6 with no more than two additions, subtractions, or substitutions,
(b) the sequence set forth in SEQ ID NO:2 or the sequence set forth in SEQ ID NO:2 with no more than one addition, subtraction, or substitution, and
(c) the sequence set forth in SEQ ID NO:7 or the sequence set forth in SEQ ID NO:7 with no more than two additions, subtractions, or substitutions.
2. The method of claim 1 , wherein said polypeptide comprises natriuretic activity.
3. The method of claim 1 , wherein said composition comprises a pharmaceutically acceptable carrier.
4. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:6, the sequence set forth in SEQ ID NO:2, and the sequence set forth in SEQ ID NO:7.
5. The method of claim 1 , wherein said polypeptide is a substantially pure polypeptide.
6. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:6.
7. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:6 with no more than two additions, subtractions, or substitutions.
8. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:6 with one addition, subtraction, or substitution.
9. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:2.
10. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:2 with one addition, subtraction, or substitution.
11. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:7.
12. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:7 with no more than two additions, subtractions, or substitutions.
13. The method of claim 1 , wherein said polypeptide comprises the sequence set forth in SEQ ID NO:7 with one addition, subtraction, or substitution.
14. The method of claim 1 , wherein said polypeptide, when administered to a mammal, induces a decrease in mean arterial pressure to a lesser extent than that induced by human BNP, when said human BNP is administered to a mammal.