IP Library › Granted Patent US 9,441,014
Granted Patent B2
US 9,441,014 · App. 14/262,453 · Granted Sep 13, 2016

Skin permeating and cell entering (SPACE) peptides and methods of use thereof

Inventors: Tracy Hsu (Newhall, CA); Samir M. Mitragotri (Santa Barbara, CA)
Assignee: The Regents of the University of California
C07K7/08A61K47/48246C07K7/06C07K7/64A61K9/127A61K38/00
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Quick Facts
Patent No.
US 9,441,014
App. No.
14/262,453
Granted
Sep 13, 2016
Kind
B2
Abstract

The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells.

Claims (18)

1. A composition comprising a peptide comprising the amino acid sequence selected from the group consisting of CHSALTKHC (SEQ ID NO:8), CKTGSHNQC (SEQ ID NO:9), CMGPSSMLC (SEQ ID NO: 10), CTDPNQLQC (SEQ ID NO: 11), CSTHFIDTC (SEQ ID NO: 12), ACTGSTQHQCG (SEQ ID NO: 13), ACHSALTKHCG (SEQ ID NO: 14), ACKTGSHNQCG (SEQ ID NO: 15), ACMGPSSMLCG (SEQ ID NO: 16), ACTDPNQLQCG (SEQ ID NO: 17), and ACSTHFIDTCG (SEQ ID NO: 18), wherein the composition is capable of penetrating a stratum corneum (SC) layer when contacted therewith or penetrating a cell when contacted therewith.

2. The composition of claim 1 , wherein the peptide comprises repeat units of one or more of CHSALTKHC (SEQ ID NO:8), CKTGSHNQC (SEQ ID NO:9), CMGPSSMLC (SEQ ID NO:10), CTDPNQLQC (SEQ ID NO:11), CSTHFIDTC (SEQ ID NO:12), ACTGSTQHQCG (SEQ ID NO:13), ACHSALTKHCG (SEQ ID NO:14), ACKTGSHNQCG (SEQ ID NO:15), ACMGPSSMLCG (SEQ ID NO:16), ACTDPNQLQCG (SEQ ID NO:17), and ACSTHFIDTCG (SEQ ID NO:18).

3. The isolated peptide of claim 2 , wherein the unit is repeated 2 to 50 times.

4. The isolated peptide of claim 2 , wherein each unit is separated by an intervening peptide sequence.

5. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 8.

6. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 9.

7. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 10.

8. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 11.

9. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 12.

10. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 13.

11. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 14.

12. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 15.

13. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 16.

14. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 17.

15. The composition of claim 1 , wherein the peptide comprises SEQ ID NO: 18.

16. The composition of claim 1 , wherein the peptide is 11 amino acids in length.

17. The composition of claim 1 , wherein the peptide is from about 12-15 amino acids in length.

18. The composition of claim 1 , wherein the peptide is from about 16-19 amino acids in length.

Assignments (2)
CONFIRMATORY LICENSE Recorded Oct 15, 2014
From: UNIVERSITY OF CALIFORNIA SANTA BARBARA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 033988/0755 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2014
From: HSU, TRACY; MITRAGOTRI, SAMIR M.
To: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Reel/Frame 033780/0583 →
Continuity (6)
Continuation 13952525 · Jul 26, 2013
Division 13253796 · Oct 5, 2011
Provisional Application 61528036 · Aug 26, 2011
Provisional Application 61527574 · Aug 25, 2011
Provisional Application 61411884 · Nov 9, 2010
Related Publication 20150025221A1 · Jan 22, 2015