Granted Patent
B2
US 9,150,511 · App. 14/264,770 · Granted Oct 6, 2015
Process for preparing saxagliptin and its novel intermediates useful in the synthesis thereof
Inventors:
Ravishanker Kovi (Monroe, NJ); KeshavRao Rapole (Edison, NJ); Ashish Naik (Piscataway, NJ); Jayaraman Kannapan (Gujrat, IN); Muralikrishna Madala (Andhra Pradesh, IN); Sanjay Thakor (Gujarat, IN)
Assignee:
Apicore US LLC
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Abstract
Methods of making saxagliptin, pharmaceutically acceptable salts and hydrates thereof and intermediates thereof.
Claims (7)
1. A method for making
comprising the steps of
treating adamantane 1-carboxylic acid with dimethyl sulfide and potassium carbonate to obtain
treating the resulting compound with a reducing agent to obtain
and
treating the resulting compound with triethylamine, dichloromethane, and oxalylchloride.
2. The method according to claim 1 wherein the reducing agent is sodium dihydro-bis-methoxyethoxy aluminate solution in toluene.
Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Sep 29, 2017
From: APICORE US LLC
To: APICORE LLC
Reel/Frame 043743/0457 →
RELEASE OF SECURITY INTEREST
Recorded Jul 17, 2017
From: MEDICURE INC.
To: APICORE US LLC
Reel/Frame 043022/0696 →
SECURITY INTEREST
Recorded Jan 31, 2017
From: APICORE US LLC
To: MEDICURE INC.
Reel/Frame 041577/0821 →
MERGER AND CHANGE OF NAME
Recorded Aug 19, 2015
From: APICORE LLC; APICORE US LLC
To: APICORE US LLC
Reel/Frame 036356/0691 →
Continuity (3)
Provisional Application
61489478
· May 24, 2011