Targeting corroles for tumor toxicity and MRI
Disclosed herein are compositions comprising a targeted corrole nanoparticle; and an acceptable excipient. Also disclosed are compositions comprising a targeted corrole nanoparticle; and an acceptable carrier. Further, disclosed herein are methods of imaging a condition in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; administering an effective amount of the targeted corrole nanoparticle to the subject; and imaging the condition in the subject. In addition, disclosed herein are methods of treating cancer in a subject, comprising providing a composition comprising a targeted corrole nanoparticle; and administering a therapeutically effective dosage of the targeted corrole nanoparticle to the subject.
1. A method of treating a cancer in a subject, comprising:
administering to the subject a therapeutically effective dosage of a composition comprising a tumor-targeted nanoparticle, wherein the tumor-targeted nanoparticle comprises a tumor-targeting polypeptide and a corrole, thereby reducing the size of the cancer;
wherein the corrole comprises manganese (Mn); and
wherein the tumor-targeting polypeptide comprises a Her segment and a penton base segment.
2. The method of claim 1 , wherein the polypeptide is a HerPBK10 molecule.
3. The method of claim 1 , wherein the nanoparticle is HerMn.
4. A method of imaging a condition in a subject using magnetic resonance imaging (MRI), comprising:
a) administering to the subject an effective amount of a composition comprising a targeted nanoparticle, wherein the targeted nanoparticle comprises a targeting polypeptide and a corrole; and
b) imaging the condition in the subject by MRI: and wherein the corrole comprises manganese (Mn),
wherein the targeting polypeptide comprises a Her segment and a penton base segment.
5. The method of claim 4 , wherein the polypeptide is a HerPBK10 molecule.
6. The method of claim 4 , wherein the nanoparticle is HerMn.
7. The method of claim 4 , wherein the condition is cancer.
8. A pharmaceutical composition comprising a tumor-targeted nanoparticle comprising a tumor-targeting polypeptide and a corrole; and a pharmaceutically acceptable carrier or excipient;
wherein the corrole comprises manganese (Mn); and
wherein the targeting polypeptide comprises a Her segment and a penton base segment.
9. The pharmaceutical composition of claim 8 , wherein the nanoparticle is HerMn.
10. The pharmaceutical composition of claim 8 , wherein the nanoparticle is targeted to a tumor cell type.
11. The method of claim 1 , wherein the corrole is S2Mn.
12. The method of claim 1 , further comprising imaging the cancer using magnetic resonance imaging (MRI).
13. The method of claim 4 , wherein the corrole is S2Mn.
14. The pharmaceutical composition of claim 8 , wherein the corrole is S2Mn.