Presbyopia treatment by lens alteration
This invention effects a change in the accommodation of the human lens affected by presbyopia through the use of various reducing agents that change accommodative abilities of the human lens, and/or by applying energy to affect a change in the accommodative abilities of the human lens. This invention both prevents the onset of presbyopia as well as treats it. By breaking and/or preventing the formation of bonds that adhere lens fibers together causing hardening of the lens, the present invention increases the elasticity and distensibility of the lens and/or lens capsule.
1. A method for reversing the effects of presybyopia comprising:
applying an external energy source to a lens of an eye; and administering a reducing agent to the lens to reduce the likelihood of reformation of lenticular disulfide bonds.
2. The method of claim 1 where the energy is of sufficient power to break lenticular disulfide bonds.
3. The method of claim 1 , wherein the energy is any form of electromagnetic radiation.
4. The method of claim 1 , wherein the energy is any form of sound energy.
5. The method of claim 1 , wherein the energy is any form of heat.
6. The method of claim 1 , wherein the reducing agent is glutathione, ascorbic acid, a thiol derivative, vitamin E, tetraethylthiuram disulfyl, ophthalmic acid, inositol, or a beta-carbolise.
7. The method of claim 1 , further comprising administering to the lens a methylating agent selected from the group consisting of methyl-methane thiosulfonate, methyl glutathione, S-methyl glutathione, S-transferase, and other biologically compatible methylating agents, wherein the reducing agent is capable of reducing the disulfide bonds into sulfhydryl groups; and wherein the methylating agent is capable of methylating the sulfhydryl groups.
8. The method of claim 7 , wherein the methylating agent comprises methyl-methane thiosulfonate.
9. The method of claim 7 , wherein the methylating agent comprises methyl glutathione.
10. The method of claim 7 , wherein the methylating agent comprises S-methyl glutathione.
11. The method of claim 7 , wherein the methylating agent comprises S-transferase.
12. The method of claim 1 , wherein the lens is a lens of a human eye.
13. The method of claim 1 , further comprising administering a catalyst to the lens.
14. The method of claim 13 , wherein the catalyst is selected from the group consisting of a reductase, an aldoreductase, a glyoxylase, a glutathione S-transferase, a thiol reductase, a tyrosine reductase, and a hexokinase.