N-hydroxylsulfonamide derivatives as new physiologically useful nitroxyl donors

Inventors: John P. Toscano (Glen Arm, MD); Frederick Arthur Brookfield (Abingdon, GB); Andrew D. Cohen (Mamaroneck, NY); Stephen Martin Courtney (Abingdon, GB); Lisa Marie Frost (Abingdon, GB); Vincent Jacob Kalish (Annapolis, MD)

Assignees: The Johns Hopkins University; Cardioxyl Pharmaceuticals, Inc.

C07D309/12 C07C311/48 C07C323/67 C07D213/74 C07D261/10 C07D263/58 C07D285/125 C07D295/096 C07D307/82 C07D317/14 C07D333/62

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Quick Facts

Patent No.: US 9,221,780
App. No.: 14/280,133
Granted: Dec 29, 2015
Kind: B2

External Links

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Abstract

The invention relates to N-hydroxysulfonamide derivatives that donate nitroxyl (HNO) under physiological conditions and are useful in treating and/or preventing the onset and/or development of diseases or conditions that are responsive to nitroxyl therapy, including heart failure and ischemia/reperfusion injury. Novel N-hydroxysulfonamide derivatives release NHO at a controlled rate under physiological conditions, and the rate of HNO release is modulated by varying the nature and location of functional groups on the N-hydroxysulfonamide derivatives.

Claims (1)

1. A compound which is

Assignments (6)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 9, 2022

From: CARDIOXYL PHARMACEUTICALS INC.

To: THE JOHNS HOPKINS UNIVERSITY

Reel/Frame 062041/0565 →

CONFIRMATORY LICENSE Recorded Oct 27, 2017

From: JOHNS HOPKINS UNIVERSITY

To: NATIONAL SCIENCE FOUNDATION

Reel/Frame 044619/0311 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 6, 2015