IP Library Granted Patent US 10,078,077
Granted Patent B2
US 10,078,077 · App. 14/283,425 · Granted Sep 18, 2018

Apparatus for automated determining of at least two different process parameters

Inventors: Michael Hanko (Dresden, DE); Angela Eubisch (Chemnitz, DE)
Assignee: Endress+Hauser Conducta Gmbh+Co. KG
G01N33/5308C12Q1/00C12Q3/00
View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 10,078,077
App. No.
14/283,425
Granted
Sep 18, 2018
Kind
B2
Abstract

An apparatus for automated determining of at least two different process parameters of a process liquid of a process, especially a bioprocess, comprising: a first measuring cell, which is embodied to provide a first measurement signal dependent on a first process parameter of a first sample of the process liquid; a second measuring cell, which is embodied to provide a second measurement signal dependent on a second process parameter of a second sample of the process liquid; and a control and evaluation system, which serves for monitoring and/or controlling the process, and which is embodied to receive and to process the first and second measurement signals, especially based on the first measurement signal to determine a measured value of the first process parameter and based on the second measurement signal to determine a measured value of the second process parameter; wherein the first measurement signal and the second measurement signal serve different functions in the context of the monitoring and/or controlling of the process. The first process parameter can be a control parameter (critical process parameter, CPP), and the second process parameter can be a product quality parameter (critical quality attribute, CQA) of the process.

Claims (26)

1. An apparatus for an automated determining of at least two different process parameters of a process liquid of a process, comprising:

a first measuring cell embodied to provide a first measurement signal dependent on a first process parameter of a first sample of the process liquid removed from a process container external to the apparatus, the first measuring cell including a first receiving space for accommodating the first sample, a first measuring transducer, and a first electronics embodied to amplify and to digitize the first measuring signal;

a second measuring cell embodied to provide a second measurement signal dependent on a second process parameter of a second sample of the process liquid removed from the process container, the second measuring cell including a second receiving space for accommodating the second sample, a second measuring transducer, and a second electronics embodied to amplify and to digitize the second measuring signal; and

a control and evaluation system embodied to receive and to process said first and second measurement signals, to determine a measured value of said first process parameter based on the first measurement signal, to determine a measured value of said second process parameter based on the second measurement signal, and to operate on the measured values to monitor and control the process,

wherein said first measurement signal and said second measurement signal serve different functions in monitoring or controlling the process.

2. The apparatus as claimed in claim 1 , wherein said first process parameter is a control parameter of the process and said second process parameter is a product quality parameter of the process.

3. The apparatus as claimed in claim 1 , wherein the apparatus is embodied to measure said first and/or second process parameter within a flow through system.

4. The apparatus as claimed in claim 1 , wherein said first process parameter is a metabolite content of the sample, including an anabolite or a catabolite content, is a content of viable cells in the sample, or is a content of dead cells in the sample.

5. The apparatus as claimed in claim 1 , wherein said second process parameter is a content of a product of the process in the liquid sample or a product activity.

6. The apparatus as claimed in claim 1 , wherein the apparatus is embodied to determine said first process parameter and/or said second process parameter by a standard addition method.

7. The apparatus as claimed in claim 1 , wherein said first or said second measuring cell is embodied for performing a solid phase bound, immunological assay for producing its measurement signal.

8. The apparatus as claimed in claim 7 , wherein the other measuring cell produces its measurement signal without performing a solid phase bound, immunological assay but with application of an optical sensor, an amperometric sensor, and/or a photometric cuvette test.

9. The apparatus as claimed in claim 7 , wherein said first measuring cell includes at least one enzyme sensor.

10. The apparatus as claimed in claim 1 , further comprising a process connection, the process connection including an apparatus for automatic sample taking and an apparatus for sample handling, wherein the first sample and the second sample are taken from the process container containing the process liquid and transported via the process connection to the first measuring cell and to the second measuring cell.

11. The apparatus as claimed in claim 10 , wherein the apparatus for sample taking is connectable to laboratory bioreactors and to process bioreactors.

12. The apparatus according to claim 1 , wherein the process is a bioprocess.

13. The apparatus according to claim 2 , wherein the control parameter is a critical process parameter of the process and the product quality parameter is a critical quality attribute of the process.

14. The apparatus of claim 6 , wherein the first process parameter or the second process parameter is a metabolite content.

15. The apparatus of claim 7 , wherein the other measuring cell produces its measurement signal with application of an optical sensor or an amperometric sensor or a photometric cuvette test.

16. An apparatus for analysis of a liquid medium, comprising:

a first measuring cell including a first receiving space for a first liquid sample, a first measuring transducer, and a first electronics, wherein the first measuring transducer is embodied to generate a first measurement signal dependent on a first process parameter, and wherein the first electronics is embodied to amplify and to digitize the first measurement signal;

a second measuring cell including a second receiving space for a second liquid sample, a second measuring transducer, and a second electronics, wherein the second measuring transducer is embodied to generate a second measurement signal dependent on a second process parameter, and wherein the second electronics is embodied to amplify and to digitize the second measurement signal;

a process connection including a sample lock, liquid transport lines, and a pump, wherein the process connection is connectable to a process container external to the apparatus, wherein the process connection is configured to remove a desired amount of liquid from the process container and to transport the desired amount of liquid from the process container to the first measuring cell and to the second measuring cell;

a plurality of reagent supply tanks, wherein the supply tanks are connected via liquid transport lines to the first measuring cell and to the second measuring cell;

a control unit embodied to receive and to process the first digital measurement signal and the second digital measurement signal and to control the operation of the apparatus; and

a cabinet, wherein the first measuring cell, the second measuring cell, the plurality of supply tanks, and the control unit are disposed within the cabinet.

Assignments (2)
CHANGE OF NAME Recorded Aug 13, 2018
From: ENDRESS + HAUSER CONDUCTA GESELLSCHAFT FÜR MESS- UND REGELTECHNIK MBH + CO. KG
To: ENDRESS+HAUSER CONDUCTA GMBH+CO. KG
Reel/Frame 046776/0170 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2014
From: HANKO, MICHAEL; EUBISCH, ANGELA
To: ENDRESS + HAUSER CONDUCTA GESELLSCHAFT FUR MESS- UND REGELTECHNIK MBH + CO. KG
Reel/Frame 032938/0653 →
Priority Claims (1)
DE 10 2013 105 492 · May 28, 2013 · national
Continuity (1)
Related Publication 20140356880A1 · Dec 4, 2014