IP Library › Granted Patent US 9,187,447
Granted Patent B2
US 9,187,447 · App. 14/291,709 · Granted Nov 17, 2015

S-nitrosoglutathione reductase inhibitors

Inventors: Xicheng Sun (Broomfield, CO); Jian Qiu (Longmont, CO)
Assignee: Nivalis Therapeutics, Inc.
C07D311/22C07D311/36C07D311/58C07D335/06C07D405/10C07D407/08C07D409/04C07D409/10C07D413/10C07D417/10
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Quick Facts
Patent No.
US 9,187,447
App. No.
14/291,709
Granted
Nov 17, 2015
Kind
B2
Abstract

The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

Claims (2)

1. A compound or a pharmaceutically acceptable salt thereof selected from the group consisting of 3-fluoro-4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)benzoic acid, 4-(7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)-3-methylbenzoic acid and 4-(8-flouoro-7-hydroxy-4-oxo-2-(trifluoromethyl)-4H-chromen-3-yl)-3-methylbenzoic acid.

2. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 together with a pharmaceutically accepted carrier or excipient.

Assignments (3)
CHANGE OF NAME Recorded Mar 4, 2015
From: N30 PHARMACEUTICALS, INC.
To: NIVALIS THERAPEUTICS, INC.
Reel/Frame 035125/0164 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 30, 2014
From: SUN, XICHENG; QIU, JIAN
To: N30 PHARMACEUTICALS, LLC
Reel/Frame 032999/0297 →
CHANGE OF NAME Recorded May 30, 2014
From: N30 PHARMACEUTICALS, LLC
To: N30 PHARMACEUTICALS, INC.
Reel/Frame 033071/0852 →
Continuity (3)
Continuation 13521833
Provisional Application 61303952 · Feb 12, 2010
Related Publication 20140275185A1 · Sep 18, 2014