Forazolines, compositions thereof and uses thereof
An isolated compound of Formula I and salts thereof are provided: wherein X is Cl or Br. A compound isolated from Actinomadura and having a chemical formula of C 43 H 69 ClN 4 O 10 S 2 or C 43 H 69 BrN 4 O 10 S 2 is also provided. Compositions including the compounds and methods of using the compounds to treat fungal infections including those such as Candida are also disclosed.
1. A method of treating a fungal infection comprising administering an effective amount of a compound of Formula I:
wherein X is Cl or Br, a salt thereof, or a pharmaceutical composition comprising the effective amount of the compound of Formula I or salt thereof and a pharmaceutically acceptable carrier, to a mammal in need thereof.
2. The method of claim 1 , wherein the mammal is human.
3. The method of claim 1 , wherein the fungal infection is caused by Candida.
4. The method of claim 1 , wherein the fungal infection is caused by Candida albicans.
5. The method of claim 1 , wherein amphotericin B is administered to the mammal in need thereof simultaneously, sequentially or separately with the compound, the salt thereof or the pharmaceutical composition.
6. The method of claim 1 , wherein a second antifungal agent is administered to the mammal in need thereof simultaneously, sequentially or separately with the compound, the salt thereof or the pharmaceutical composition.
7. The method of claim 1 , wherein the compound of Formula I has the Formula IA:
wherein X is Cl or Br.
8. The method of claim 7 , wherein the mammal is human.
9. The method of claim 7 , wherein the fungal infection is caused by Candida.
10. The method of claim 7 , wherein the fungal infection is caused by Candida albicans.
11. The method of claim 7 , wherein the pharmaceutical composition of the method is formulated for parenteral or topical administration.
12. The method of claim 7 , wherein amphotericin B is administered to the mammal in need thereof simultaneously, sequentially or separately with the compound, the salt thereof or the pharmaceutical composition.
13. The method of claim 7 , wherein a second antifungal agent is administered to the mammal in need thereof simultaneously, sequentially or separately with the compound, the salt thereof or the pharmaceutical composition.
14. The method of claim 1 , wherein the compound of Formula I has the Formula IB:
15. The method of claim 14 , wherein the mammal is human.
16. The method of claim 14 , wherein the fungal infection is caused by Candida.
17. The method of claim 14 , wherein the fungal infection is caused by Candida albicans.
18. The method of claim 14 , wherein the pharmaceutical composition of the method is formulated for parenteral or topical administration.
19. The method of claim 14 , wherein amphotericin B is administered to the mammal in need thereof simultaneously, sequentially or separately with the compound, the salt thereof or the pharmaceutical composition.
20. The method of claim 14 , wherein a second antifungal agent is administered to the mammal in need thereof simultaneously, sequentially or separately with the compound, the salt thereof or the pharmaceutical composition.