Sleep monitoring and stimulation

1. A method comprising:

estimating an initial sleep phase;

determining an inactivity period comprising a period of fifteen to twenty minutes;

causing at least one stimulation device to direct an increasing intensity of stimulation towards a user in response to the inactivity period, wherein the stimulation is:

determined, at least in part, by the initial sleep phase to induce a micro-arousal without altering a sleep pattern associated with the initial sleep phase; and

applied externally as at least one of a tactile stimulation and an auditory stimulation for one to five seconds;

in response to the increasing intensity of stimulation:

collecting from at least one actigraphy device, actigraphy data from the user;

monitoring one or more of the stimulation, actigraphy data, or physiological responses;

determining one or more of the stimulation, actigraphy data, or physiological responses exceeds a threshold;

augmenting the actigraphy data based at least in part on the threshold; and

collecting physiological responses of the user;

modifying, as a second increasing intensity of stimulation, the stimulation by increasing one or more of a volume or intensity of stimulation without changing the sleep pattern;

applying the second increasing intensity of simulation for a one to five seconds;

determining one or more of a change in heart rate or a change in breathing, and

in response to changes in the actigraphy data and physiological responses:

determining a current sleep phase of the user based at least in part on the current intensity of the increasing intensity of stimulation; and

stopping, based at least in part on the one or more of the change in heart rate or the change in breathing, the increasing intensity of the stimulation.

2. The method according to claim 1 , further comprising:

causing the at least one stimulation device to direct a subsequent increasing intensity of stimulation towards the user, the subsequent increasing intensity of stimulation determined, at least in part, on the sleep phase;

collecting from the at least one actigraphy device, subsequent actigraphy data from the user;

collecting subsequent physiological responses of the user to the subsequent stimulation; and

determining a subsequent sleep phase of the user employing the subsequent physiological responses, and the subsequent actigraphy data,

wherein the actigraphy data and subsequent actigraphy data are stored in bins of 30-60 seconds.

3. The method according to claim 1 , further comprising determining when the user changes between two sleep phases, employing, at least in part, data collected during prior sleep sessions.

4. The method according to claim 1 , wherein the stimulation further comprises one or more of electrical stimulation or transcranial stimulation,

the method further comprising: applying a subsequent increasing intensity of stimulation to the user to cause a subsequent physiological response, the subsequent stimulation based upon the user's sleep phase.

5. The method according to claim 1 , further comprising modifying the increasing intensity of stimulation based on time spent in a sleep phase.

6. The method according to claim 1 , further comprising modifying the increasing intensity of stimulation when the actigraphy data indicates that the user is changing sleep phases.

7. The method according to claim 1 , further stopping the increasing intensity of stimulation when the actigraphy data indicates that the user is waking.

8. The method according to claim 1 , wherein the stimulation comprises a plurality of stimulations.

9. The method according to claim 1 , wherein the stimulation comprises a plurality of stimulations and one of the plurality of stimulations comprises at least one inactive stimulation.

10. The method according to claim 1 , wherein the sleep phase may comprise at least one of the following:

a. rapid eye movement sleep phase (REM);

b. Non-REM Stage 1 (N1) light sleep phase;

c. Non-REM Stage 1 (N2) intermediate sleep phase;

d. Non-REM Stage 1 (N3) deep sleep phase; and

e. an awake phase.

11. The method according to claim 1 , wherein the physiological responses comprises a change in body temperature,

wherein a declining body temperature is indicative of a progression to a deeper sleep stage.

12. The method according to claim 1 , wherein the physiological responses comprise at least one of the following:

a. sound data;

b. breathing rate data;

d. blood pressure data;

f. blood oxygenation data;

g. perspiration data;

j. location data; and

k. a combination thereof.

13. The method according to claim 1 , wherein the at least one stimulation device comprises an auditory device and a tactile stimulation device.

14. The method according to claim 1 , wherein the stimulation further comprises at least one of the following:

a neuro-stimulation comprising a transcranial stimulation or

electrical stimulation.

15. The method of claim 1 , further comprising:

determining, based at least in part on the actigraphy data, an activity period of each minute of actigraphy data associated with a largest integrated acceleration;

determining, as a number of counts and based at least in part on the activity period, a maximum number of zero-crossings for each minute of actigraphy data, wherein the zero-crossings are the actigraphy data crossing a zero value of actigraphy with respect to time; and

determining a logistic regression of a weighted average of the number of counts; and

determining, based at least in part on the logistic regression, whether the user is asleep or awake.

16. A system for determining a sleep phase comprising:

one or more processors; and

one or more non-transitory computer readable media having instructions stored thereon which, when executed by the one or more processors, cause the one or more processors to perform operations comprising:

estimating an initial sleep phase;

determining an inactivity period;

causing at least one stimulation device to direct an increasing intensity of stimulation towards a user in response to the inactivity period, wherein the stimulation is:

determined, at least in part, by the initial sleep phase to induce a micro-arousal without altering a sleep pattern associated with the initial sleep phase; and

applied externally as at least one of a tactile stimulation and an auditory stimulation;

in response to the increasing intensity of stimulation:

collecting from at least one actigraphy device, actigraphy data from the user; and

collecting physiological responses of the user; and

in response to changes in the actigraphy data and physiological responses:

determining a current sleep phase of the user based at least in part on the current intensity of the increasing intensity of stimulation; and

stopping the increasing intensity of the stimulation,

wherein determining the current sleep phase comprises:

determining, based at least in part on the actigraphy data, an activity period of each minute of actigraphy data associated with a largest integrated acceleration;

determining, as a number of counts and based at least in part on the activity period, a maximum number of zero-crossings for each minute of actigraphy data, wherein the zero-crossings are the actigraphy data crossing a zero value of actigraphy with respect to time;

determining a weighted average of the number of counts; and

determining, based at least in part on the weighted average, whether the user is asleep or awake.

17. The system of claim 16 ,

wherein the activity period is ten seconds,

wherein the weighted average comprises a weighted average of:

a first number of counts, A-4, associated with a first minute four minutes before a current minute,

a second number of counts, A-3, associated with a second minute three minutes before the current minute,

a third number of counts, A-2, associated with a third minute two minutes before the current minute,

a fourth number of counts, A-1, associated with a fourth minute one minute before the current minute,

a fifth number of counts, A0, associated with the current minute,

a sixth number of counts, A+1, associated with a sixth minute one minute after the current minute, and

a seventh number of counts, A+2, associated with a seventh minute two minutes after the current minute.

18. The system of claim 17 , the operations further comprising determining a logistic regression of the weighted average,

wherein determining whether the user is asleep or awake is further based at least in part on the logistic regression, and

wherein determining the logistic regression comprises:

determining, as a sum, S, 0.010(A-4)+0.015(A-3)+0.28(A-2)+0.031(A-1)+0.085(A0)+0.015(A+1)+0.010(A+2); and

determining, as the logistic regression, a product of S and a polynomial scalar, P, and

wherein determining whether the user is awake comprises determining the logistic regression is greater than one,

the method further comprising:

determining, as a circadian amplitude, a ratio of an average activity during wakeful periods and an average activity during restful periods.

19. The system of claim 16 , the operations further comprising:

monitoring one or more of the stimulation, actigraphy data, or physiological responses;

determining one or more of the stimulation, actigraphy data, or physiological responses exceeds a threshold; and

augmenting the actigraphy data based at least in part on the threshold.