IP Library › Granted Patent US 9,441,036
Granted Patent B2
US 9,441,036 · App. 14/302,986 · Granted Sep 13, 2016

Anti-IL-23 antibodies

Inventors: Rachel Rebecca Barrett (Bethel, CT); Keith Canada (Southbury, CT); Katrina Mary Catron (Middlebury, CT); Robert Copenhaver (Portland, OR); Lee Edward Frego (Hopewell Junction, NY); Ernest Lee Raymond (New Milford, CT); Sanjaya Singh (Sandy Hook, CO); Xiangyang Zhu (Ridgefield, CT)
Assignee: BOEHRINGER INGELHEIM INTERNATIONAL GMBH
C07K16/244C12N15/113A61K2039/505C07K2317/24C07K2317/34C07K2317/76C07K2317/92
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Quick Facts
Patent No.
US 9,441,036
App. No.
14/302,986
Granted
Sep 13, 2016
Kind
B2
Abstract

The present invention relates to anti-IL-23p19 binding compounds, in particular new humanized anti-IL-23p19 antibodies and therapeutic and diagnostic methods and compositions for using the same.

Claims (14)

1. An isolated polynucleotide comprising a sequence encoding a light chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:158, 160, 162 or 164, or encoding a heavy chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO: 166, 168, 170 or 172.

2. An isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:174 or 180, or encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:176 or 178.

3. An isolated polynucleotide according to claim 1 , said isolated polynucleotide comprising a sequence encoding a light chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:160 or encoding a heavy chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:166.

4. An isolated polynucleotide according to claim 1 , said isolated polynucleotide comprising a sequence encoding a light chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:160 or encoding a heavy chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:168.

5. An isolated polynucleotide according to claim 1 , said isolated polynucleotide comprising a sequence encoding a light chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:158 or encoding a heavy chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:166.

6. An isolated polynucleotide according to claim 1 , said isolated polynucleotide comprising a sequence encoding a light chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:158 or encoding a heavy chain variable region of an antibody or antibody fragment having the amino acid sequence of SEQ ID NO:168.

7. An isolated polynucleotide according to claim 2 , said isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:174 or encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:176.

8. An isolated polynucleotide according to claim 2 , said isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:174 or encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:178.

9. An isolated polynucleotide according to claim 2 , said isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:180 or encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:176.

10. An isolated polynucleotide according to claim 2 , said isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:180 or encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:178.

11. An isolated polynucleotide according to claim 2 , said isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:174 and encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:176.

12. An isolated polynucleotide according to claim 2 , said isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:174 and encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:178.

13. An isolated polynucleotide according to claim 2 , said isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:180 and encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:176.

14. An isolated polynucleotide according to claim 2 , said isolated polynucleotide comprising a sequence encoding a light chain of an antibody having the amino acid sequence of SEQ ID NO:180 and encoding a heavy chain of an antibody having the amino acid sequence of SEQ ID NO:178.

Continuity (6)
Division 13287208 · Nov 2, 2011
Provisional Application 61448785 · Mar 3, 2011
Provisional Application 61412594 · Nov 11, 2010
Provisional Application 61411953 · Nov 10, 2010
Provisional Application 61410158 · Nov 4, 2010
Related Publication 20140363444A1 · Dec 11, 2014