Neuroprotection by hepatic cells and hepatocyte secretory factors
The present invention relates to compositions and methods for neuroprotection. In particular, provided herein are compositions (e.g., hepatocyte secretory factors) for alleviating and/or protecting against neuronal damage (e.g., resulting from stroke), and methods of use thereof.
1. A method of treating a subject experiencing cerebral ischemia comprising: administering a composition to said subject, wherein said composition comprises at least one isolated hepatocyte secretory factor which is RELMγ.
2. The method of claim 1 , wherein administration of said composition reduces ischemic injury in said subject.
3. The method of claim 1 , wherein administration of said composition exerts a neuroprotective effect.
4. The method of claim 1 , wherein administration of said composition results in reduction in cerebral infarction.
5. The method of claim 1 , wherein said subject is a mammal.
6. The method of claim 5 , wherein said subject is a human.