Fasting condition as dietary treatment of diabetes
A method of alleviating symptoms of, or treating, pancreatic beta-cell damage in a subject includes a step of identifying a subject having pancreatic beta-cell damage. Multiple cycles of a diet protocol are administered to the subject. The diet protocol includes administering of a fasting mimicking diet and a re-feeding diet where the fasting mimicking diet is provided for a first time period and the re-feeding diet is provided for a second time period.
1. A method of treating a symptom of diabetes, the method comprising:
identifying a subject exhibiting symptoms caused by pancreatic beta cell destruction, the subject having a normal caloric intake; and
administering multiple cycles of a diet protocol to the subject wherein a fasting mimicking diet is provided for a first time period and a re-feeding diet is provided for a second time period, the fasting mimicking diet providing less than about 50% of the normal caloric intake of the subject with both protein restriction and sugar restriction and the re-feeding diet providing 60-100 percent of the normal caloric intake of the subject, depending on a need to lose weight wherein the first time period is from 2 days to 6 days and the second time period is from 7 days to 85 days.
2. The method of claim 1 wherein the multiple cycles are administered once a month for at least 3 months.
3. The method of claim 1 further comprising:
monitoring response of the subject to the diet protocol; and
adjusting the diet protocol if the response of the subject is determined to be inadequate by increasing the first time period and/or reducing caloric intake during the first time period.
4. The method of claim 1 wherein the subject is diagnosed with diabetes mellitus type 1.
5. The method of claim 1 wherein the fasting mimicking diet includes protein in an amount that is less than 15 percent of total calories provided by the fasting mimicking diet.
6. The method of claim 1 wherein the fasting mimicking diet includes sugars in an amount that is less than 15 percent of total calories provided by the fasting mimicking diet.
7. The method of claim 1 wherein the fasting mimicking diet provides the subject with 4.5 to 7 kcal/pound of body weight/day on day 1 followed by 3 to 5 kcal/pound of body weight/day for days 2 to 5.
8. The method of claim 1 wherein the fasting mimicking diet provides the subject with 7 kcal/pound of body weight/day on day 1 followed by 4 kcal/pound of body weight/day for days 2-5.
9. The method of claim 1 wherein the fasting mimicking diet provides the subject with 3-6 kcal/pound of body weight/day on day 1 followed by 2-4 kcal/pound of body weight/day for days 2-4.
10. The method of claim 1 wherein the fasting mimicking diet includes 2 to 5% calories from glycerol.
11. The method of claim 1 wherein the fasting mimicking diet includes at least 60% calories from fatty acids, 2-5% calories from glycerol and up to 5% of calories from plant-based proteins, and a maximum of 35% of calories from carbohydrates.
12. The method of claim 11 wherein the fasting mimicking diet includes complex carbohydrate from plant sources.
13. The method of claim 12 wherein the plant sources include soy, rice, or other grains.
14. The method of claim 11 wherein at least 50% of the calories from fatty acids are from coconut oil and tree nuts.
15. The method of claim 14 wherein the tree nuts include macadamia nuts, walnuts, or almonds.
16. A method of treating a symptom of diabetes, the method comprising:
identifying a subject exhibiting symptoms caused by pancreatic beta-cell damage, the subject having a normal caloric intake; and
administering multiple cycles of a diet protocol to the subject wherein a fasting mimicking diet is provided for a first time period of 2 days to 6 days and a re-feeding diet is provided for a second time period of 7 days to 45 days, the fasting mimicking diet providing less than about 50% of the normal caloric intake of the subject with both protein restriction and sugar restriction and the re-feeding diet providing at least 60 percent of the normal caloric intake of the subject.
17. The method of claim 16 wherein the multiple cycles are administered for at least 60 days.
18. The method of claim 16 further comprising:
monitoring response of the subject to the diet protocol; and
adjusting the diet protocol if the response of the subject is determined to be inadequate by increasing the first time period and/or reducing caloric intake during the first time period.
19. The method of claim 16 wherein the subject is diagnosed with diabetes mellitus type 1, diabetes mellitus type 2, or pre-diabetes.
20. The method of claim 16 wherein the fasting mimicking diet includes protein in an amount that is less than 15 percent of total calories provided by the fasting mimicking diet.
21. The method of claim 16 wherein the fasting mimicking diet includes sugars in an amount that is less than 15 percent of total calories provided by the fasting mimicking diet.
22. The method of claim 16 wherein the fasting mimicking diet provides the subject with 4.5 to 7 kcal/pound of body weight/day on day 1 followed by 3 to 5 kcal/pound of body weight/day for days 2 to 5.
23. The method of claim 16 wherein the fasting mimicking diet provides the subject with 3-6 kcal/pound of body weight/day on day 1 followed by 2-4 kcal/pound of body weight/day for days 2-4.
24. The method of claim 16 wherein the fasting mimicking diet includes 2 to 5% calories from glycerol.
25. A method of alleviating insulin resistance and/or hyperglycemia, the method comprising:
identifying a subject having or being predisposed to insulin resistance and/or fasting hyperglycemia diabetes; and
administering multiple cycles of a diet protocol to the subject wherein a fasting mimicking diet is provided for a first time period and a re-feeding diet is provided for a second time period, the fasting mimicking diet providing less than about 50% of the normal caloric intake of the subject with both protein restriction and sugar restriction and the re-feeding diet providing 60-100 percent of the normal caloric intake of the subject, depending on a need to lose weight, wherein the fasting mimicking diet is provided to the subject for 4-5 days every 4-12 weeks to promote a reduction in symptoms.
26. The method of claim 15 wherein the subject has a family history of insulin resistance and/or fasting hyperglycemia diabetes.
27. The method of claim 25 wherein the subject exhibits a trending towards insulin resistance and/or fasting hyperglycemia diabetes.
28. A method of alleviating metabolic syndrome, the method comprising:
identifying a subject having or being predisposed to metabolic syndrome; and
administering multiple cycles of a diet protocol to the subject wherein a fasting mimicking diet is provided for a first time period and a re-feeding diet is provided for a second time period, the fasting mimicking diet providing less than about 50% of the normal caloric intake of the subject with both protein restriction and sugar restriction and the re-feeding diet providing 60-100 percent of the normal caloric intake of the subject, depending on a need to lose weight, wherein the fasting mimicking diet is provided to the subject for 4-5 days every 4-12 weeks to promote a reduction in symptoms.
29. The method of claim 28 wherein the subject has a family history of insulin resistance and/or fasting hyperglycemia diabetes.