4′-O-substituted isoindoline derivatives and compositions comprising and methods of using the same
Provided are 4′-O substituted isoindoline compounds, and pharmaceutically acceptable salts, solvates, clathrates, stereoisomers, and prodrugs thereof. Methods of use, and pharmaceutical compositions of these compounds are disclosed.
1. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
Y is CH 2 or C═O;
R 5 is aryl, optionally substituted with one, two or three groups selected from alkyl, halo, alkoxy, carboxy, alkylaminocarbonyl, alkoxycarbonyl, nitro, amine, nitrile, haloalkyl, hydroxy, alkylaminocarboxy, and alkylsulfonyl; and
n 1 is 0-5 1-5.
2. The compound of claim 1 , wherein Y is CH 2 .
3. The compound of claim 1 , wherein Y is C═O.
4. The compound of claim 1 , wherein the aryl is phenyl.
5. The compound of claim 1 , wherein the aryl is naphthyl.
6. The compound of claim 4 , wherein the phenyl is substituted with halo.
7. The compound of claim 5 , wherein the naphthyl is substituted with halo.
8. The compound of claim 4 , wherein the phenyl is substituted with alkyl or alkoxy.
9. The compound of claim 5 , wherein the naphthyl is substituted with alkyl or alkoxy.
10. The compound of claim 1 , which is:
11. The compound of claim 1 , which is:
12. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
Y is CH 2 or C═O;
R 5 is aryl, optionally substituted with one, two or three groups selected from alkyl, halo, alkoxy, carboxy, alkylaminocarbonyl, alkoxycarbonyl, nitro, amine, nitrile, haloalkyl, hydroxy, alkylaminocarboxy, and alkylsulfonyl; and
n 1 is 0.
13. The compound of claim 12, wherein Y is CH 2 .
14. The compound of claim 12, wherein Y is C═O.
15. The compound of claim 12, wherein the aryl is phenyl.
16. The compound of claim 12, wherein the aryl is naphthyl.
17. The compound of claim 15, wherein the phenyl is substituted with halo.
18. The compound of claim 16, wherein the naphthyl is substituted with halo.
19. The compound of claim 15, wherein the phenyl is substituted with alkyl or alkoxy.
20. The compound of claim 16, wherein the naphthyl is substituted with alkyl or alkoxy.
21. The compound of claim 12, which is:
22. A compound of formula:
or a pharmaceutically acceptable salt or stereoisomer thereof,
wherein:
Y is CH 2 or C═O;
R 5 is naphthyl; and
n 1 is 1-5.
23. The compound of claim 22, wherein Y is CH 2 .
24. The compound of claim 22, wherein Y is C═O.
25. The compound of claim 22, which is: