Methods and compositions comprising desmopressin in combination with a 5-alpha reductase inhibitor
The invention provides methods and compositions for use of desmopressin in combination with a 5-alpha reductase inhibitor. The methods and compositions are useful in the treatment of nocturia and other urinary frequency disorders.
1. A method of inhibiting in an adult human subject the urge to urinate over an interval of about two hours to no more than about eight hours while reducing the risk that the human subject develops hyponatremia, comprising administering to an adult human subject in need thereof active agents consisting of an effective, low dose amount of desmopressin and a 5-alpha reductase inhibitor so that both exert physiological activity during an overlapping time period, wherein when the 5-alpha reductase inhibitor is dutasteride or finasteride, the dose is lower than 0.5 mg/day for dutasteride and is lower than 5 mg/day for finasteride.
2. The method of claim 1 , wherein the administering achieves in the subject a blood plasma concentration of desmopres sin that does not exceed 15 pg/mL.
3. The method of claim 1 , wherein the administering achieves in the subject a blood plasma concentration of desmopres sin that does not exceed 10 pg/mL.
4. The method of claim 1 , wherein the administering achieves in the subject a blood plasma concentration of desmopressin in the range of about 0.5 pg/mL to about 5 pg/mL.
5. The method of claim 1 , wherein the administering achieves in the human subject a blood plasma concentration of desmopressin in the range of about 0.5 pg/mL to about 2.5 pg/mL.
6. The method of claim 1 , wherein desmopressin is administered transdermally, intradermally, or transmucosally across the oral or nasal mucosa.
7. The method of claim 1 , wherein desmopressin is administered transdermally or intradermally.
8. The method of claim 1 , wherein desmopressin is administered intranasally.
9. The method of claim 1 , wherein desmopressin is administered sublingually across the oral mucosa.
10. The method of claim 7 , wherein desmopressin is administered at a flux rate ranging from about 5 ng/hour to about 35 ng/hour.
11. The method of claim 7 , wherein desmopressin is administered at a flux rate ranging from about 5 ng/hour to about 15 ng/hour.
12. The method of claim 1 , wherein the 5-alpha reductase inhibitor is dutasteride, epristeride, finasteride, izonsteride, turosteride, AS-601811, FK143, TF-505, or a pharmaceutically acceptable salt thereof.
13. The method of claim 1 , wherein the method inhibits in a human subject the urge to urinate over an interval of about four hours to about seven hours.
14. The method of claim 1 , wherein an antidiuretic effect is achieved over an interval of about two hours to no more than about six hours.
15. The method of claim 1 , wherein an antidiuretic effect is achieved over an interval of about four hours to no more than about seven hours.
16. The method of claim 1 , wherein when the 5-alpha reductase inhibitor is dutasteride, the dose is 0.1 to 0.3 mg/day.
17. The method of claim 1 , wherein when the 5-alpha reductase inhibitor is finasteride, the dose is less than 1.0 mg/day.