IP Library Granted Patent US 10,258,531
Granted Patent B2
US 10,258,531 · App. 14/342,050 · Granted Apr 16, 2019

Systems and methods for inhibiting apneic events

Inventors: David Paydarfar (Newton, MA); Riccardo Barbieri (Boston, MA); Premananda Pai Indic (Northborough, MA); Ruby Kandah (Boston, MA); James Brian Niemi (Concord, MA); John Paul Osborne (Winchester, MA); Hani M. Sallum (Somerville, MA); Amanda V. Wozniak (Somerville, MA)
Assignees: PRESIDENT AND FELLOWS OF HARVARD COLLEGE; THE GENERAL HOSPITAL CORPORATION; UNIVERSITY OF MASSACHUSETTS
A61H1/005A61B5/01A61B5/02055A61B5/03A61B5/0468A61B5/0816A61B5/11A61B5/4818A61B5/4836A61B5/6892A61B5/7275A61F5/56A61H1/001A61H23/0245A61M21/02G06F19/00A61B5/024A61M2021/0022
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Quick Facts
Patent No.
US 10,258,531
App. No.
14/342,050
Granted
Apr 16, 2019
Kind
B2
Abstract

Systems and methods are disclosed to monitor physiological for the occurrence of life threatening events and to apply stimulation to prevent the occurrence of said life-threatening events. Systems and methods for applying the stimulation are also disclosed. These systems include applying the stimulation through via a mattress having a passive section and an active section, a plurality of focal stimulators, and/or an array to apply the stimulation are also disclosed. These devices include a mattress with an active region and a passive region, a stimulating array do deliver targeted stimulation, and a plurality of stimulators to apply focused stimulation.

Claims (17)

1. A method for inhibiting a future apneic event comprising steps of:

monitoring physiological data of an infant with one or more sensors, the one or more sensors comprising a respiration sensor, the physiological data including measurements of an interbreath interval of the infant;

receiving the physiological data from the one or more sensors into a sensor and data acquisition system;

producing the physiological data from the sensor and data acquisition system to input to a signal processor;

analyzing, via an algorithm of the signal processor, the input physiological data to detect an impending apneic event;

predicting the impending apneic event using a point-process model, the predicting being based on a variance, σ 2 , of the measurements and a predetermined threshold value of the interbreath interval, the predetermined threshold value indicating a predetermined event of the impending apneic event;

comparing via a compare module the variance to the predetermined threshold value;

determining that the variance is greater than the predetermined threshold value; and

based on the determining, automatically applying a subarousal vibrational stimulation to the infant via a physical stimulator to inhibit occurrence of the impending apneic event by reducing or eliminating the variance, the physical stimulator interacting with one or more body parts of the infant, the subarousal vibrational stimulation including stochastic resonance stimulation.

2. The method of claim 1 wherein the subarousal vibrational stimulation is a vibrational stimulus applied through a mattress.

3. The method of claim 1 wherein the subarousal vibrational stimulation is applied to focused areas on the body of the infant.

4. The method of claim 1 wherein the physical stimulator includes at least one actuator.

5. The method of claim 1 wherein the receiving step and the analyzing step occur in real time.

6. The method of claim 1 , further comprising sending a notification to an individual regarding the impending apneic event.

7. The method of claim 1 , wherein the physiological data includes other respiratory data.

8. The method of claim 1 , wherein the physiological data includes cardiological data.

9. The method of claim 1 , wherein the physiological data includes body motion data.

Assignments (4)
CONFIRMATORY LICENSE Recorded Nov 17, 2014
From: HARVARD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034274/0194 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2014
From: PAYDARFAR, DAVID; INDIC, PREMANANDA PAI
To: UNIVERSITY OF MASSACHUSETTS
Reel/Frame 032808/0370 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2014
From: BARBIERI, RICCARDO
To: THE GENERAL HOSPITAL CORPORATION
Reel/Frame 032808/0388 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 2, 2014
From: KANDAH, RUBY; NIEMI, JAMES; OSBORNE, JOHN PAUL; SALLUM, HANI M.; WOZNIAK, AMANDA
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 032808/0435 →
Continuity (2)
Provisional Application 61528994 · Aug 30, 2011
Related Publication 20140303458A1 · Oct 9, 2014