Compositions and methods for treating cancer
View Patent ↗The instant invention provides a method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer and ovarian cancer, by administering a combination of a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, or MK-3652 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof, or SCH900444 or a pharmaceutically acceptable salt thereof.
1. A method of treating a cancer, selected from the group consisting of breast cancer, melanoma, colorectal cancer, non-small cell lung cancer, and ovarian cancer, with a WEE1 inhibitor and a CHK1 inhibitor, wherein the WEE1 inhibitor is MK-1775 or a pharmaceutically acceptable salt thereof, and the CHK1 inhibitor is MK-8776 or a pharmaceutically acceptable salt thereof.
2. A method of claim 1 for treating a cancer patient, in need of treatment thereof, comprising administering to said patient a therapeutically effective amount of said WEE1 inhibitor and said CHK1 inhibitor.
3. The method of claim 2 wherein the WEE1 inhibitor is administered in a dose between 100 mg per day and 250 mg per day.
4. The method of claim 3 wherein the WEE1 inhibitor is administered five times, over the course of two and a half days.
5. The method of claim 3 wherein the WEE1 inhibitor is administered once a day, over the course of two days.
6. The method of claim 2 wherein the CHK1 inhibitor is administered in a dose between 100 mg per day and 200 mg per day.
7. The method of claim 6 wherein the CHK1 inhibitor is administered once a day, over the course of two days.