Anti-human norovirus GII antibody

1. An anti-human-norovirus GII antibody that binds to epitopes in an amino acid region represented by (i), (ii), and (iii):

(i) an epitope in an amino acid region of at least one amino acid sequence of formula (1):

P-X 1 -X 2 -P-G-E  (1) (SEQ ID NO: 2)

wherein

X 1 represents L, V, N, T, S, M, or R;

X 2 represents F, Y, S or M;

(ii) an epitope in an amino acid region of at least one amino acid sequence of formula (2)

X 3 -X 4 -X 5 -F-Y-X 6 -L-X 7 -P-X 8   (2) (SEQ ID NO: 3)

wherein

X 3 represents V or G;

X 4 represents N or S;

X 5 represents Q, P, or S;

X 6 represents S, T, or I;

X 7 represents A or S; and

X 8 represents M or V; and

(iii) an epitope in an amino acid region comprising amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1, or comprising an amino acid corresponding to amino acid 483 of the amino acid sequence represented by SEQ ID NO: 1,

wherein the amino acid region represented by (i), (ii), and (iii) is present in a P domain of a capsid structural protein of a human norovirus GII.

2. The anti-human-norovirus GII antibody according to claim 1 , wherein the amino acid region represented by formula (1) is a region from amino acid 419 to amino acid 424 of the amino acid sequence represented by SEQ ID NO: 1, and the amino acid region represented by formula (2) is a region from amino acid 516 to amino acid 525 of the amino acid sequence represented by SEQ ID NO: 1.

3. A human norovirus GII detection reagent comprising the antibody of claim 1 .

4. A method for detecting a human norovirus GII, the method comprising reacting a specimen suspected to contain the human norovirus GII with the antibody of claim 1 , and performing an immunological assay to detect the virus.

5. A human norovirus GII detection reagent comprising the antibody of claim 2 .

6. A method for detecting a human norovirus GII, the method comprising reacting a specimen suspected to contain the human norovirus GII with the antibody of claim 2 , and performing an immunological assay to detect the virus.

7. The anti-human-norovirus GII antibody of claim 1 , wherein the amino acid region represented by formula (1) is a region from amino acid 419 to amino acid 424 of the amino acid sequence represented by SEQ ID NO: 1.

8. The anti-human-norovirus GII antibody of claim 1 , wherein the amino acid region represented by formula (2) is a region from amino acid 516 to amino acid 525 of the amino acid sequence represented by SEQ ID NO: 1.

9. The anti-human-norovirus GII antibody according to claim 1 , wherein X 2 in the amino acid sequence of formula (1) is F.

10. The anti-human-norovirus GII antibody according to claim 1 , wherein the amino acid sequence of formula (1) is selected from the group consisting of:

P-L-F-P-G-E  (1-1)(SEQ ID NO: 4),

P-V-F-P-G-E  (1-2) (SEQ ID NO: 5),

P-N-F-P-G-E  (1-3) (SEQ ID NO: 6),

P-T-F-P-G-E  (1-4) (SEQ ID NO: 7),

P-S-F-P-G-E  (1-5)(SEQ ID NO: 8),

P-T-Y-P-G-E  (1-6) (SEQ ID NO: 9),

P-M-F-P-G-E  (1-7) (SEQ ID NO: 10),

P-R-M-P-G-E  (1-9) (SEQ ID NO: 12).

11. The anti-human-norovirus GII antibody according to claim 1 , wherein X 3 in the amino acid sequence of formula (2) is V.

12. The anti-human-norovirus GII antibody according to claim 1 , wherein X 4 in the amino acid sequence of formula (2) is N.

13. The anti-human-norovirus GII antibody according to claim 1 , wherein X 5 in the amino acid sequence of formula (2) is Q.

14. The anti-human-norovirus GII antibody according to claim 1 , wherein X 6 in the amino acid sequence of formula (2) is S or T.

15. The anti-human-norovirus GII antibody according to claim 1 , wherein X 7 in the amino acid sequence of formula (2) is A.

16. The anti-human-norovirus GII antibody according to claim 1 , wherein X 8 in the amino acid sequence of formula (2) is M.

17. The anti-human-norovirus GII antibody according to claim 1 , wherein the amino acid sequence of formula (2) is selected from the group consisting of:

V-N-Q-F-Y-S-L-A-P-M  (2-1)(SEQ ID NO: 13),

V-N-P-F-Y-T-L-A-P-M  (2-2) (SEQ ID NO: 14),

V-N-Q-F-Y-T-L-A-P-M  (2-3) (SEQ ID NO: 15),

V-N-Q-F-Y-T-L-A-P-V  (2-4) (SEQ ID NO: 16),

V-N-Q-F-Y-S-L-A-P-M  (2-5) (SEQ ID NO: 17),

G-N-Q-F-Y-T-L-A-P-M  (2-6) (SEQ ID NO: 18),

V-N-Q-F-Y-S-L-A-P-V  (2-7) (SEQ ID NO: 19), and

V-S-S-F-Y-I-L-S-P-V  (2-8) (SEQ ID NO: 20).