Use of strigolactones and strigolactone analogs for treating proliferative conditions
Compound of formula X wherein P 1 is a fused-ring system comprising one 6-membered and two 5-membered rings; v indicates an S or R configuration; or individual isomers or pharmaceutically acceptable salts thereof, or mixtures thereof, in the preparation of an active agent for preventing or inhibiting cell proliferation or for inducing cell death.
1. A method for inhibiting the proliferation of a cancerous cell in a patient in need thereof, or for inducing death of a cancerous cell in a patient in need thereof, wherein said cancerous cell comes from cancer selected from the group consisting of breast cancer, lung cancer, prostate cancer, colon cancer, leukemia and osteosarcoma, said method comprising the step of administering to said patient an effective amount of a compound of formula III
or its stereoisomer or pharmaceutically acceptable salt thereof;
wherein R 1 is C 1 -C 6 alkyl;
Z is CH, and Y is N;
R 6 is H or C 1 -C 6 alkyl;
R 2 and R 5 represent H; and
one of R 3 and R 4 represents H whereas the other is selected from the group consisting of H, Halogen, C 1 -C 6 alkyl, heterocyclyl, cycloalkyl, benzcycloalkyl, thienyl, 2,3-dihydrothieno[3,4-b][1,4]dioxin-7-yl, and phenyl or naphthyl substituted with nitro, dialkylamino or methoxy group.
2. The method of claim 1 , wherein the compound of formula III or its stereoisomer or pharmaceutically acceptable salt is part of a pharmaceutical composition.
3. The method of claim 2 , wherein the pharmaceutical composition further comprises one or more additional pharmaceutically active compounds.
4. The method of claim 1 , wherein the compound of formula III is selected from the group consisting of:
(±)(2E)-4-methyl-2-(4-methyl-5-oxo-2,5-dihydrofuran-2-yloxymethylene)-1,4-dihydro-2H-cyclopenta[b]indol-3-one;
(±)(2E)-7-bromo-4-methyl-2-(4-methyl-5-oxo-2,5-dihydrofuran-2-yloxymethylene)-1,4-dihydro-2H-cyclopenta[b]indol-3-one;
(±)(2E)-4-methyl-2-(4-methyl-5-oxo-2,5-dihydrofuran-2-yloxymethylene)-7-(4-nitrophenyl)-1,4-dihydro-2Hcyclopenta[b]indol-3-one;
(±)(2E)-4-methyl-2-(4-methyl-5-oxo-2,5-dihydrofuran-2-yloxymethylene)-7-(2-thienyl)-1,4-dihydro-2H-cyclopenta[b]indol-3-one;
(±)(2E)-4-methyl-2-(4-methyl-5-oxo-2,5-dihydrofuran-2-yloxymethylene)-7-[(4-dimethylamino)-phenyl]-1,4-dihydro-2H-cyclopenta[b]indol-3-one;
(2E)-7-(1-methoxynaphthalen-2-yl)-1,4-dimethyl-2-((4-methyl-5-oxo-2,5-dihydrofuran-2-yloxy)methylene)-1,2-dihydrocyclopenta[b]indol-3(4H)-one;
(2E)-2-[(2,5-dihydro-4-methyl-5-oxofuran-2-yloxy)methylene]-1,2-dihydro-7-[4-(dimethylamino)pheny]-1,4-dimethyl-cyclopenta[b]indole-3-(4H)-one;
(2E)-1,4-dimethyl-2-((4-methyl-5-oxo-2,5-dihydrofuran-2-yloxy)methylene)-7-(thiophen-2-yl)-1,2-dihydrocyclopenta[b]indol-3(4H)-one;
(2E)-2-[(2,5-dihydro-4-methyl-5-oxofuran-2-yloxy)methylene]-1,2-dihydro-7-(2,3-dihydrothieno[3,4-b][1,4]dioxin-7-yl)-1,4-dimethylcyclopenta[b]indole-3-(4H)-one;
(±)2E-4-methyl-2-(4-methyl-5-oxo-2,5-dihydrofuran-2-yloxymethylene)-6-thiophen-2-yl-1,4-dihydro-2H-cyclopenta[b]indol-3-one;
and any combinations thereof.