Pharmaceutical compounds for use in the therapy of
The invention relates to a compound described by a general formula (1), wherein each X independently can be OPO 3 2− , OPSO 2 2− or OSO 3 − ; R 1 comprises a solubility function such as a polyethylene glycol moiety and each X independently can be OPO 3 2− , OPSO 2 2− , − or OSO 3 − ; and Z is an alkyl chain comprising 1 to 3 carbon and/or hetero atoms. The invention further relates to polysulfate derivatives or mixed polyphosphate/sulphate derivatives of six-membered cyclic polyols for use in the therapy of infection by Clostridium difficile.
1. A method for treating a C. difficile infection, comprising administering to a subject a composition comprising a compound described by general formula (16a) or (16b):
wherein
a) X 2 is OSO 3 − , and X 1 , X 3 , X 4 , X 5 and X 6 are each independently selected from OPO 3 2− , OPSO 2 2− or OSO 3 − ;
b) X 1 , X 3 and X 5 are OPO 3 2− and X 2 , X 4 and X 6 are OSO 3 −
c) X 1 , X 3 and X 5 are OSO 3 − and X 2 , X 4 and X 6 are OPO 3 2−
d) X 4 , X 5 and X 6 are OSO 3 − and X 1 , X 2 and X 3 are OPO 3 2− ,
e) X 4 , X 5 and X 6 are OPO 3 2− and X 1 , X 2 and X 3 are OSO 3 − or
f) X 2 and X 5 are OPO 3 2− and X 1 , X 3 , X 4 , and X 6 are OSO 3 − ,
g) X 2 and X 5 are OSO 3 − and X 1 , X 3 , X 4 , and X 6 are OPO 3 2− ,
h) X 2 and X 3 are OPO 3 2− and X 1 , X 4 , X 5 , and X 6 are OSO 3 − , or
i) X 2 and X 3 are OSO 3 − and X 1 , X 4 , X 5 , and X 6 are OPO 3 2− .
2. The method of claim 1 , wherein the composition further comprises an antibiotic.
3. The method of claim 2 , wherein the antibiotic is metronidazole, vancomycin or fidaxomicin.