Triazolyl PDE10 inhibitors

1. A compound of the formula I:

wherein:

W, X, Y, and Z are independently selected from the group consisting of:

X=Y=N and Z=W=C,

X=Z=N and Y=W=C, and

Y=Z=N and X=W=C,

R represents H, or C 1-6 alkyl,

R 1 is selected from the groups consisting of, (CH 2 ) n OR, (CH 2 ) n C 3-10 cycloalkyl, (CH 2 ) n C 6-10 aryl, C 1-6 alkyl, and (CH 2 ) n C 5-10 heterocycle, said alkyl, cycyloalkyl, heterocycle, and aryl optionally substituted with 1 to 3 groups of R a ;

R 2 is selected from the group consisting of:

(1) halogen,

(2) C 1-6 alkyl, which is unsubstituted or substituted with 1 to 3 groups of R a ,

(3),

(4) —(CH 2 ) n C 5-10 heterocycle, which is unsubstituted or substituted with 1 to 3 groups of R a ,

(5) —(CH 2 ) n C 3-10 cycloalkyl, which is unsubstituted or substituted with 1 to 3 groups of R a ,

(6) C 2-6 alkenylC 5-10 heterocycle, which is unsubstituted or substituted with 1 to 3 groups of R a ;

(7) C 2-6 alkynylC 5-10 heterocycle, which is unsubstituted or substituted with 1 to 3 groups of R a ; and

(8) C 2-6 alkenyl, which is unsubstituted or substituted with 1 to 3 groups of R a ;

R 3 and R 4 are absent when Z or W is N, and are independently selected from the group consisting of H, —O—R, CN, O(CH 2 ) n OR, —OCHR(CH 2 ) n OR, SR, SO 2 R, S(O)R, C(O)N(R) 2 , C 1-3 haloalkyl, O(CH 2 ) n C 1-3 haloalkyl, —O(CH 2 ) n C 3-6 cycloalkyl, (CH 2 ) n C 5-10 heterocycle, —O(CH 2 ) n C 5-10 heterocycle, C 1-6 alkyl, and C 3-10 cycloalkyl when Z or W is C, said alkyl, cycloalkyl, and heterocycle unsubstituted or substituted with 1 to 3 groups of R a ;

R 5 and R 6 are absent when X or Y is N, and are independently selected from the group consisting of H, and CN, when X or Y is C;

R 7 is selected from the group consisting of C 1-6 alkyl, or halo;

R a is selected from the group consisting of:

(1) halogen,

(2) hydroxyl,

(3) C 1-6 alkyl,

(4) —(CH 2 ) n O—R,

(5) (CH 2 ) n C 6-10 aryl,

(6) (CH 2 ) n C 5-10 heterocycle,

(7) OC 1-5 haloalkyl;

(8) CO 2 R;

(9) C(O)N(R) 2 ;

(10) (CH 2 ) n C(O)R;

(11) CN,

(12) (CH 2 ) n N(R) 2 ;

(13) (CH 2 ) n C 3-6 cycloalkyl,

(14) (CH 2 ) n C 1-3 haloalkyl;

said cycloalkyl, aryl and heterocycle optionally substituted with 1 to 3 groups of R b ;

R b is selected from the group consisting of (CH 2 ) n C 1-3 haloalkyl; (CH 2 ) n C 3-6 cycloalkyl, (CH 2 ) n C 5-10 heterocycle, (CH 2 ) n C 6-10 aryl, (CH 2 ) n N(R) 2 , halogen, CN, OC 1-4 haloalkyl, C 1-6 alkyl, and OR, said heterocycle unsubstituted or substituted with 1 to 3 groups of C 1-6 alkyl; and

n represents 0-4,

or a pharmaceutically acceptable salt thereof, wherein C 5-10 heterocycle is a stable 5- to 7-membered monocyclic or stable 8- to 11-membered bicyclic heterocyclic ring which is either saturated or unsaturated, and which consists of carbon atoms and from one to four heteroatoms selected from the group consisting of N, O, and S and R 1 and R 7 are not both hydrogen at the same time and R 2 and R 3 are not C 1-6 alkyl at the same time.

2. The compound according to claim 1 wherein R 2 is selected from the group consisting of halogen, (CH 2 ) n C 3-10 cycloalkyl, (CH 2 ) n C 5-10 heterocycle, C 2-6 alkenyl, C 2-6 alkenylC 5-10 heterocycle, C 2-6 alkynylC 5-10 heterocycle, said heterocycle, alkenyl, and cycloalkyl optionally substituted with 1 to 3 groups of R a .

3. The compound according to claim 2 wherein R 2 is selected from the group consisting of chlorine, fluorine, optionally substituted cyclopropyl, quinolinyl, pyrimidinyl, pyridyl, and naphthyridinyl, optionally substituted C 2-6 alkenylC 5-10 heterocycle, C 2-6 alkynylC 5-10 heterocycle, wherein the heterocycle on the alkenyl-heterocycle and alkynyl-heterocycle is selected from the group consisting of quinolinyl, pyrimidinyl, pyridyl, and naphthyridinyl.

4. The compound according to claim 1 wherein R 3 , when present, is selected from the group consisting of hydrogen, C 1-6 alkyl, O(CH 2 ) 2 OH, OR, O(CH 2 ) 2 OCH 3 , OCHRCH 2 OCH 3 , SR, O(CH 2 ) n CH 2 F, O(CH 2 ) n CF 3 , C(O)N(R) 2 , N(R) 2 , or optionally substituted O(CH 2 ) n C 3-6 cycloalkyl, (CH 2 ) n C 5-10 heterocycle, C 1 -6alkyl, and C 3-10 cycloalkyl and R 4 , when present, is hydrogen.

5. The compound according to claim 1 wherein R 1 is C 1-6 alkyl, (CH 2 ) n C 3-10 cycloalkyl, (CH 2 ) n C 6-10 aryl, and (CH 2 ) n C 5-10 heterocycle, wherein the cycloalkyl, aryl and heterocycle are selected from the group consisting of optionally substituted phenyl, tetrahydrofuranyl, pyranyl, piperidinyl, cyclohexyl, pyridyl, thiazolyl, pyrazinyl, cyclopropyl and cyclohexyl.

6. The compound according to claim 1 wherein X=Y=N and Z=W=C, R 1 is selected from the group consisting of optionally substituted C 1-6 alkyl, (CH 2 ) n phenyl, (CH 2 ) n pyrazinyl, and (CH 2 ) n pyridyl, R 5 and R 6 are absent, R 7 is methyl, R 3 is methyl, and R 2 is cyclopropyl substituted with one optionally substituted benzimidazole.

7. The compound according to claim 1 wherein X=Z=N and Y=W=C, R 1 is selected from the group consisting of optionally substituted C 1-6 alkyl, (CH 2 ) n phenyl, (CH 2 ) n pyrazinyl, and (CH 2 ) n pyridyl, R 5 and R 6 are absent, R 7 is methyl, R 3 is methyl, and R 2 is cyclopropyl substituted with one optionally substituted benzimidazole substituted with optionally substituted benzimidazole.

8. The compound according to claim 1 wherein Y=Z=N and X=W=C, R 1 is selected from the group consisting of optionally substituted C 1-6 alkyl, (CH 2 ) n phenyl, (CH 2 ) n pyrazinyl, and (CH 2 ) n pyridyl, R 5 and R 6 are absent, R 7 is methyl, R 3 is methyl, and R 2 is cyclopropyl substituted with one optionally substituted benzimidazole.

9. The compound according to claim 1 of formula I represented by structural formula II:

or a pharmaceutically acceptable salt thereof.

10. The compound according to claim 1 of formula I represented by structural formula IIa:

or a pharmaceutically acceptable salt thereof.

11. The compound according to claim 10 wherein R 1 is C 1-6 alkyl, (CH 2 ) n C 3-10 cycloalkyl, (CH 2 ) n C 6-10 aryl, and (CH 2 ) n C 5-10 heterocycle, wherein the cycloalkyl, aryl and heterocycle are selected from the group consisting of optionally substituted phenyl, tetrahydrofuranyl, pyranyl, piperidinyl, cyclohexyl, pyridyl, thiazolyl, pyrazinyl, cyclopropyl and cyclohexyl and wherein there is one R a off of the cyclopropyl, said R a selected from the group consisting of halogen, CO 2 R, COR, (CH 2 ) n C 5-10 heterocycle, and (CH 2 ) n C 6-10 aryl, said heterocyle and aryl optionally substituted with 1 to 3 groups of R b and the aryl and heterocycle off the cyclopropyl is selected from the group consisting of optionally substituted pyridyl, benzimidazolyl, thiazolyl, dihydropyrrolopyrazolyl, imidazolylpyridinyl, tetrahydropyrazolopyridinyl, naphthyridinyl, oxadiazolyl, thiadiazolyl, and benzthiazolyl.

12. The compound according to claim 1 of formula I represented by structural formula III:

or a pharmaceutically acceptable salt thereof, Y′ is selected from the group consisting of —CH 2 CH 2 , —C≡C—, —CH═CH—, and —OCH 2 —, and R 2a is C 5-10 heterocycle, said heterocycle optionally substituted with 1 to 3 groups of R a .

13. The compound according to claim 12 wherein R 2a is selected from the group consisting of pyrimidinyl, quinolinyl, pyridyl, and naphthyridinyl, any of which are optionally substituted with 1 to 3 groups of R a , R 1 is selected from the group consisting of optionally substituted methyl, ethyl, propyl, isopropyl, butyl, (CH 2 )phenyl, cyclopropyl, cyclohexyl, (CH 2 )thiazolyl, (CH 2 )pyrazinyl, (CH 2 ) 0-1 pyridyl, piperidinyl, pyranyl, and pyrrolidinyl, and R 2a is selected from the group consisting of optionally substituted pyrimidinyl, quinolinyl, pyridyl, and naphthyridinyl substituted with 1 to 3 groups of R a .

14. A compound which is:

4-chloro-6-(5-(3,4-dimethoxybenzyl)-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine,

2-((6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)ethynyl)quinoline,

2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)ethyl)quinoline,

2-((6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yloxy)methyl)quinoline,

4-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-(2-(5-methylpyridin-2-yl)ethyl)pyrimidine,

4-chloro-6-(5-((5,6-dimethoxypyridin-2-yl)methyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine,

2-((6-(5-((5,6-dimethoxypyridin-2-yl)methyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)ethynyl)quinoline,

2-(2-(6-(5-((5,6-dimethoxypyridin-2-yl)methyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)ethyl)quinoline,

2,5-dimethyl-4-((3-methyl-1-(2-methyl-6-(quinolin-2-ylmethoxy)pyrimidin-4-yl)-1H-1,2,4-triazol-5-yl)methyl)thiazole,

4-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-vinylpyrimidine,

4-chloro-6-(5-((5,6-dimethoxypyrazin-2-yl)methyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine,

(E)-2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)vinyl)-1,5-naphthyridine,

2-((6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)ethynyl)-1,5-naphthyridine,

2-(2-(6-(5-((5,6-dimethoxypyrazin-2-yl)methyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)ethyl)quinoline,

2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)ethyl)-1,5-naphthyridine,

trans-ethyl-2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropanecarboxylate,

(E)-2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)vinyl)quinoline,

(E)-4-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-(2-(pyridin-2-yl)vinyl)pyrimidine,

(E)-4-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-(2-(5-methylpyridin-2-yl)vinyl)pyrimidine,

2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropanecarboxylic acid,

2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)-N-methylcyclopropanecarboxamide,

1-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)ethanone,

5-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-3-methyl-1,2,4-oxadiazole,

2-((1S,2S)-2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1H-benzo[d]imidazole,

2-((1R,2R)-2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1H-benzo[d]imidazole,

2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-5-methyl-1,3,4-oxadiazole,

2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-5-methyl-1,3,4-thiadiazole,

4-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-6-(2-iodocyclopropyl)-2-methylpyrimidine,

4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-chloropyrimidine,

4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-vinylpyrimidine,

Ethyl-2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropanecarboxylate,

Trans-2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1,5-naphthyridine,

Cis-2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1,5-naphthyridine,

4-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-(2-(5-methylpyridin-2-yl)cyclopropyl)pyrimidine,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

2-((1R,2R)-2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1H-benzo[d]imidazole,

3,5-dimethyl-1-(2-methyl-6-(2-(5-methyl-1,3,4-oxadiazol-2-yl)cyclopropyl)pyrimidin-4-yl)-1H-1,2,4-triazol-4-ium,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-5-methyl-1,3,4-thiadiazole,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1H-benzo[d]imidazole,

2-(2-(6-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazole,

4-(5-(3,4-dimethoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-6-(2-(5-methoxypyridin-2-yl)cyclopropyl)-2-methylpyrimidine,

4-(5-benzyl-3-methyl-1H-1,2,4-triazol-1-yl)-6-chloro-2-methylpyrimidine,

4-chloro-6-(5-(4-methoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine,

4-(5-benzyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-vinylpyrimidine,

4-(5-(4-methoxybenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-vinylpyrimidine,

4-chloro-6-(5-isopropyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidine,

4-(5-benzyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-(2-(5-methylpyridin-2-yl)cyclopropyl)pyrimidine,

4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-(2-(5-methylpyridin-2-yl)ethyl)pyrimidine,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1-phenyl-1H-benzo[d]imidazole,

1-benzyl-2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1H-benzo[d]imidazole,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-6-fluoro-1H-benzo[d]imidazole,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-5,6-difluoro-1H-benzo[d]imidazole,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-7-methyl-1H-benzo[d]imidazole,

2-(2-(6-(5-isopropyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

6-chloro-2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1H-benzo[d]imidazole,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-6-methyl-1H-benzo[d]imidazole,

2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-6-methoxy-1H-benzo[d]imidazole,

6-(difluoromethoxy)-2-(2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)cyclopropyl)-1H-benzo[d]imidazole,

4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-[(1R,2R)-2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidine-2-carbonitrile,

4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-N-methyl-6-[(1R,2R)-2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-2-amine,

2-{(1R,2R)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-ethoxypyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

2-({4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-[(1R,2R)-2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-2-yl}oxy)ethanol,

2-{(1R,2R)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(2-methoxyethoxyl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

2-[(1R,2R)-2-{6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-[(1R)-2-methoxy-1-methylethoxy]pyrimidin-4-yl}cyclopropyl]-1-methyl-1H-benzimidazole,

2-[(1R,2R)-2-{6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-[(1S)-2-methoxy-1-methylethoxy]pyrimidin-4-yl}cyclopropyl]-1-methyl-1H-benzimidazole,

2-{(1R,2R)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-6-fluoro-1H-benzimidazole,

2-{(1R,2R)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(methylsulfanyl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-(tetrahydro-2H-pyran-2-ylmethyl)-1H-benzimidazole,

2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-(1-methylethyl)-1H-benzimidazole,

2-(2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1H-benzimidazol-1-yl)-N,N-dimethylethanamine,

2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-(pyridin-2-ylmethyl)-1H-benzimidazole,

2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-(pyridin-3-ylmethyl)-1H-benzimidazole,

2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-(tetrahydrofuran-2-ylmethyl)-1H-benzimidazole,

2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-(pyridin-4-ylmethyl)-1H-benzimidazole,

1-methyl-2-{(1R,2R)-2-[2-methyl-6-(3-methyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl]cyclopropyl}-1H-benzimidazole,

3-methyl-1-{2-methyl-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl}-1H-1,2,4-triazol-5-ol,

2-{2-[6-(5-cyclohexyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-imidazo[4,5-b]pyridine,

1-methyl-2-{2-[2-methyl-6-(3-methyl-5-pyridin-3-yl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl]cyclopropyl}-1H-benzimidazole,

1-methyl-2-{2-[2-methyl-6-(3-methyl-5-pyridin-2-yl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl]cyclopropyl}-1H-benzimidazole,

2-{2-[6-(5-ethyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

tert-butyl 4-(3-methyl-1-{2-methyl-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl}-1H-1,2,4-triazol-5-yl)piperidine-1-carboxylate,

2-{2-[6-(5-cyclopropyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

2-[2-{6-[5-(methoxymethyl)-3-methyl-1H-1,2,4-triazol-1-yl]-2-methylpyrimidin-4-yl}cyclopropyl]-1-methyl-1H-benzimidazole,

N,N-dimethyl-1-(3-methyl-1-{2-methyl-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl}-1H-1,2,4-triazol-5-yl)methanamine,

2-{(1R,2R)-2-[6-(3-bromo-5-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

2-{(1R,2R)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1H-benzimidazole,

2-{(1S,2S)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1H-benzimidazole,

2-[(1R,2R)-2-{6-[5-(methoxymethyl)-3-methyl-1H-1,2,4-triazol-1-yl]-2-methylpyrimidin-4-yl}cyclopropyl]-1-methyl-1H-benzimidazole,

2-{(1R,2R)-2-[6-(5-ethyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

2-[(1R,2R)-2-{6-[5-(fluoromethyl)-3-methyl-1H-1,2,4-triazol-1-yl]-2-methylpyrimidin-4-yl}cyclopropyl]-1-methyl-1H-benzimidazole,

2-[(1R,2R)-2-{6-[5-(methoxymethyl)-1H-1,2,4-triazol-1-yl]-2-methylpyrimidin-4-yl}cyclopropyl]-1-methyl-1H-benzimidazole,

2-[(1R,2R)-2-(6-{5-[(1S)-1-methoxyethyl]-3-methyl-1H-1,2,4-triazol-1-yl}-2-methylpyrimidin-4-yl)cyclopropyl]-1-methyl-1H-benzimidazole,

1-methyl-2-[(1R,2R)-2-{2-methyl-6-[3-methyl-5-(1-methylpiperidin-4-yl)-1H-1,2,4-triazol-1-yl]pyrimidin-4-yl}cyclopropyl]-1H-benzimidazole,

1-methyl-2-[(1R,2R)-2-{2-methyl-6-[3-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-1,2,4-triazol-1-yl]pyrimidin-4-yl}cyclopropyl]-1H-benzimidazole,

2-(3-methyl-1-{2-methyl-6-[(1R,2R)-2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-4-yl}-1H-1,2,4-triazol-5-yl)propan-2-ol,

2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]ethyl}-1,5-naphthyridine,

2-{(1R,2R)-2-[6-(5-tert-butyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

1-methyl-2-[(1R,2R)-2-(2-methyl-6-{3-methyl-5-[(2S)-tetrahydrofuran-2-yl]-1H-1,2,4-triazol-1-yl}pyrimidin-4-yl)cyclopropyl]-1H-benzimidazole,

2-{(1S,2S)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-(2-fluoroethyl)-1H-benzimidazole,

2-{(1S,2S)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-(2-fluoroethyl)-1H-benzimidazole,

2-{(1S,2S)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1,3-benzothiazole,

4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-{(1S,2S)-2-[5-(1-methyl-1H-pyrazol-3-yl)-1,3,4-thiadiazol-2-yl]cyclopropyl}pyrimidine,

2-{(1R,2R)-2-[6-(3,5-diethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

2-{(1R,2R)-2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methoxypyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[2-cyclopropyl-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(1-methylethoxyl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-N,N-dimethyl-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-2-amine,

trans-4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]-N-methylethyl)pyrimidin-2-amine,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-pyrrolidin-1-ylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-morpholin-4-ylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-N-tert-butyl-4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-2-amine,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-ethylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[2-(cyclopropylmethoxy)-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(4-methylpiperazin-1-yl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(2-fluoroethoxyl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-2-amine,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(2,2,2-trifluoroethoxyl)pyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidin-2-ol,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-piperazin-1-ylpyrimidin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}quinoline,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)pyridazin-4-yl]cyclopropyl}-1-methyl-1H-benzimidazole,

trans-2-{2-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl]cyclopropyl}-1,3-benzothiazole,

trans-4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-[2-(1-methyl-1H-benzimidazol-2-yl)cyclopropyl]pyrimidine-2-carboxamide,

2-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-((1R,2R)-2-(1-methyl-1H-benzo[d]imidazol-2-yl)cyclopropyl)pyrimidin-2-yl)propan-2-ol,

2-((1R,2R)-2-(2-(3,3-difluoroazetidin-1-yl)-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

2-((1R,2R)-2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-((R)-2-methylpyrrolidin-1-yl)pyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

2-((1R,2R)-2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-((R)-3-fluoropyrrolidin-1-yl)pyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

1-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-((1R,2R)-2-(1-methyl-1H-benzo[d]imidazol-2-yl)cyclopropyl)pyrimidin-2-yl)-3-methylazetidin-3-ol,

2-((1R,2R)-2-(2-cyclobutoxy-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

2-((1R,2R)-2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-((1-methylcyclopropyl)methoxy)pyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

2-((1R,2R)-2-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(oxetan-2-ylmethoxy)pyrimidin-4-yl)cyclopropyl)-1-methyl-1H-benzo[d]imidazole,

or a pharmaceutically acceptable salt thereof.

15. A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.

16. A method for treating anxiety in a mammalian patient in need thereof which comprises administering to the patient a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable salt thereof.