1,3 substituted azetidine PDE10 inhibitors

1. A compound of the formula I:

wherein:

X 1 , X 2 and X 3 independently are CH, or N

R is selected from the group consisting of H, and C 1-6 alkyl;

R 2 is selected from the group consisting of H, O—C 1-6 alkyl, C 1-6 alkyl, C 1-3 haloalkyl, (CH 2 ) n C 3-10 cycloalkyl, CN; (CH 2 ) n C 5-10 heterocycle, said alkyl, cycloalkyl, and heterocycle, optionally substituted with 1 to 3 groups of R a ;

R 3 is selected from the group consisting of NRC(O)R 6 , C(O)OR 6 , and (CH 2 ) n C 5-10 heterocycle, said heterocycle, optionally substituted with 1 to 3 groups of R a ;

R 5 is (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocycle, (CH 2 ) n C 3-10 cycloalkyl, said cycloalkyl, heterocycle, and aryl optionally substituted with 1 to 3 groups of R a ;

R 6 is selected from the groups consisting of H, C 1-6 alkyl, OR, (CH 2 ) n C 3-10 cycloalkyl, —NH(CH 2 ) n OR, (CH 2 ) n C 6-10 aryl, —N(R) 2 , (CH 2 ) n C 6-10 heterocyle, said alkyl, cycloalkyl, heterocycle, and aryl optionally substituted with 1 to 3 groups of R a ;

R a is selected from the group consisting of:

(1) halogen,

(2) hydroxyl,

(3) C 1-6 alkyl, which is unsubstituted or substituted with 1 to 3 groups of R b ,

(4) —O—C 1-6 alkyl, which is unsubstituted or substituted with 1 to 3 groups of R b ,

(5) (CH 2 ) n C 6-10 aryl, which is unsubstituted or substituted with 1 to 3 groups of R b ,

(6) —O—(CH 2 ) n C 5-10 heterocycle, which is unsubstituted or substituted with 1 to 3 groups of R b ,

(7) —(CH 2 ) n C 5-10 heterocycle, which is unsubstituted or substituted with 1 to 3 groups of R b ,

(8) —O—(CH 2 ) n C 6-10 aryl, which is unsubstituted or substituted with 1 to 3 groups of R b

(9) —(CH 2 ) n C 6-10 aryl, which is unsubstituted or substituted with 1 to 3 groups of Rb

(10) —O—(CH 2 ) n C 3-10 cycloalkyl, which is unsubstituted or substituted with 1 to 3 groups of R b ,

(11) —(CH 2 ) n C 3-10 cycloalkyl, which is unsubstituted or substituted with 1 to 3 groups of R b ,

(12) —NH—C 1-6 alkyl, or —N(C 1-6 alkyl)(C 1-6 alkyl), which is unsubstituted or substituted with 1 to 3 groups of R b ,

(13) —O—(CH 2 ) n SO 2 C 6-10 aryl, which is unsubstituted or substituted with 1 to 3 groups of R b

(14) —(CH 2 ) n CO 2 R,

(15) —CN,

(16) —NO 2 ;

(17) —O) 0-1 C 1-5 haloalkyl;

(18) C 2-6 alkynylC 5-10 heterocycle, which is unsubstituted or substituted with 1 to 3 groups of R b ;

(19) C 2-6 alkenyl;

(20) C(O)R,

(21) NH(CH 2 ) n OR, —NH(CH 2 ) n C 6-10 aryl, —NH(CH 2 ) n C 3-10 cycloalkyl, —NH(CH 2 ) n C 1-6 alkyl, —NRR, —NHC(O)C 1-6 alkyl, —N(C 1-6 alkyl)(CH 2 ) n C 6-10 aryl, or —NHSO 2 C 1-6 alkyl, said alkyl, cycloalkyl and aryl optionally substituted with 1 to 3 groups of R b

R b is selected from the group consisting of:

(1) halogen,

(2) hydroxyl,

(3) C 1-6 alkyl,

(4) —O—C 1-6 alkyl,

(5) (CH 2 )nC 6-10 aryl,

(6) (CH 2 ) n C 5-10 heterocycle,

(7) C 1-5 haloalkyl; and

n represents 0-4;

or a pharmaceutically acceptable salt thereof.

2. The compound according to claim 1 wherein R 3 is (CH 2 ) n C 5-10 heterocycle, said heterocycle optionally substituted with 1 to 3 groups of Ra.

3. The compound according to claim 2 wherein R 3 is selected from the group consisting of pyrimidinyl, pyrimidinon-yl, pyridyl, pyridinon-yl, benzimidazoly, thiazolyl, oxazolyl, thiadiazolyl, imidazolyl, benzoxazolyl, naphthyridinyl, quinolinyl, isoquinolinyl, pyrazolopyridinyl, imidazopyridinyl, and imidazopyrimidinyl, said groups optionally substituted with 1 to 3 groups of R a .

4. The compound according to claim 1 wherein R 3 is selected from the group consisting of NRC(O)R 6 , and C(O)OR 6 .

5. The compound according to claim 1 wherein at least one of X 1 , X 2 and X 3 is nitrogen.

6. The compound according to claim 5 wherein two of X 1 , X 2 and X 3 is nitrogen and the other is CH.

7. The compound according to claim 1 wherein R 5 is selected from the group consisting of triazolyl, imidazolyl, pyrazolyl, pyradazinyl, pyrimidinyl, pyrazinyl, triazinyl, pyridyl, and piperazinyl, said groups optionally substituted with 1 to 3 groups of R a .

8. The compound according to claim 7 wherein R 5 is triazoly, pyridyl, pyrazolyl, or pyridazinyl, said group optionally substituted with 1 to 3 groups of R a .

9. The compound according to claim 1 of formula I represented by structural formula II:

or a pharmaceutically acceptable salt thereof, wherein R 2 , and R a are as originally described, and R 1 is selected from the groups consisting of H, O—C 1-6 alkyl, C 1-6 alkyl, (CH 2 ) n C 3-10 cycloalkyl, (CH 2 ) n C 6-10 aryl, and (CH 2 ) n C 5-10 heterocycle, said alkyl, heterocycle, and aryl optionally substituted with 1 to 3 groups of R b .

10. The compound according to claim 9 wherein R 2 is CN, CF 3 , CF 2 , C 1-6 alkyl, O—C 1-6 alkyl, C 3-10 cycloalkyl, or (CH 2 ) n C 5-10 heterocyle, R 1 is (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocyle, or C 1-6 alkyl, said alkyl, cycloalkyl heterocycle, and aryl optionally substituted with 1 to 3 groups of R b .

11. The compound according to claim 1 of formula I represented by structural formula III:

or a pharmaceutically acceptable salt thereof, wherein R 2 , and R a are as originally described, B is pyridyl, and R 1 is selected from the groups consisting of H, O—C 1-6 alkyl, C 1-6 alkyl, (CH 2 ) n C 3-10 cycloalkyl, (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocycle, said alkyl, heterocycle, and aryl optionally substituted with 1 to 3 groups of R b .

12. The compound according to claim 11 wherein R 2 is CN, CF 3 , CF 2 , C 1-6 alkyl, O—C 1-6 alkyl, C 3-10 cycloalkyl, or (CH 2 ) n C 5-10 heterocyle, R 1 is (CH 2 ) n C 6-10 aryl, (CH 2 ) n C 5-10 heterocyle, or C 1-6 alkyl, said alkyl, cycloalkyl heterocycle, and aryl optionally substituted with 1 to 3 groups of R b .

13. A compound which is:

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(4-methyl-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(2-methoxy-6-(4-methyl-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(6-(4-methyl-1H-pyrazol-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(2-cyclopropyl-6-(4-methyl-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-pyrazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3,4-dimethyl-1H-pyrazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(3,4,5-trimethyl-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(3-(trifluoromethyl)-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(3-methoxy-1H-pyrazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3-cyclopropyl-1H-pyrazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3-isopropyl-1H-pyrazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(4-ethyl-1H-pyrazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(4-(trifluoromethyl)-1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-pyrazole-4-carbonitrile,

2-(1-(6-(4-methoxy-1H-pyrazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

(1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-pyrazol-4-yl)methanol,

1-(1-{2-methoxy-6-3-(1-methyl-1H-benzimidazol-2-yl)azetidin-1-yl]pyrimidin-4-yl}-1H-pyrazol-4-yl)ethanol,

1-methyl-2-(1-(2-methyl-6-(5-methyl-3-(trifluoromethyl)-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(3,5-diethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(methylthio)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

methyl 4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidine-2-carboxylate,

2-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-2-yl)acetonitrile,

ethyl 2-(4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-2-yl)acetate,

1-methyl-2-(1-(2-methyl-6-(5-methyl-1H-1,2,3-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(4-methyl-2H-1,2,3-triazol-2-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(4-methyl-1H-1,2,3-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(6-(4-methyl-1H-1,2,3-triazol-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(6-(4-methyl-2H-1,2,3-triazol-2-yl)-2-(trifluoromethyl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(2-cyclopropyl-6-(4-methyl-1H-1,2,3-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(2-cyclopropyl-6-(4-methyl-2H-1,2,3-triazol-2-yl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-{1-[2-methoxy-6-(4-methyl-2H-1,2,3-triazol-2-yl)pyrimidin-4-yl]azetidin-3-yl}-1-methyl-1H-benzimidazole,

2-(1-(6-(5-ethyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(5-cyclopropyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(3-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(3-methyl-5-propyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(5-isopropyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

(S)-1-(3-methyl-1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-1,2,4-triazol-5-yl)propan-2-ol,

(R)-1-(3-methyl-1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-1,2,4-triazol-5-yl)propan-2-ol,

2-(1-(6-(5-(2-methoxyethyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

methyl 3-(3-methyl-1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-1,2,4-triazol-5-yl)propanoate,

ethyl 2-(3-methyl-1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-1,2,4-triazol-5-yl)acetate,

2-(1-(6-(5-cyclohexyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(3-methyl-5-(phenoxymethyl)-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-4-(3-methyl-1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-1,2,4-triazol-5-yl)pyrrolidin-2-one,

1-((3-methyl-1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-1,2,4-triazol-5-yl)methyl)pyrrolidin-2-one,

1-methyl-2-(1-(2-methyl-6-(3-methyl-5-phenyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(5-(2-chlorophenyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(5-(2-fluorophenyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(3-methyl-5-(pyridin-3-yl)-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(3-methyl-5-(5-methylpyrazin-2-yl)-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

4-(3-methyl-1-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)-1H-1,2,4-triazol-5-yl)benzonitrile,

1-methyl-2-(1-(2-methyl-6-(3-methyl-5-(6-methylpyridin-3-yl)-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(5-(2,6-difluorophenyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(5-(2,5-difluorobenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(5-(4-fluorobenzyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-{6-[5-(methoxymethyl)-3-methyl-1H-1,2,4-triazol-1-yl]-2-methylpyrimidin-4-yl}azetidin-3-yl)-1-methyl-1H-benzimidazole,

2-{1-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl]azetidin-3-yl}-1-methyl-1H-benzimidazole,

2-{1-[2-cyclopropyl-6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl]azetidin-3-yl}-1-methyl-1H-benzimidazole,

2-{1-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methoxypyrimidin-4-yl]azetidin-3-yl}-1-methyl-1H-benzimidazole,

2-(1-(6-(5-cyclopropyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methoxypyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(5-ethyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-methoxypyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(2-cyclopropyl-6-(5-(methoxymethyl)-3-methyl-1H-1,2,4-triazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(5-(methoxymethyl)-3-methyl-1H-1,2,4-triazol-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(5-ethyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(5-cyclopropyl-3-methyl-1H-1,2,4-triazol-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(6-(3-methyl-5-(tetrahydro-2H-pyran-4-yl)-1H-1,2,4-triazol-1-yl)-2-(trifluoromethyl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-{1-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-isopropoxypyimidin-4-yl]azetidin-3-yl}-1-methyl-1H-benzimidazole,

5-(((4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-2-yl)oxy)methyl)isoxazole,

2-(((4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-2-yl)oxy)methyl)thiazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(1-methyl-1H-pyrazol-5-yl)methoxy)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

3-(((4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-2-yl)oxy)methyl)isoxazole,

5-(((4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-2-yl)oxy)methyl)-3-methyl-1,2,4-oxadiazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(1H-pyrazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(2-methyl-1H-imidazol-1-yl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-{1-[6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-(pyrrolidin-1-yl)pyrimidin-4-yl]azetidin-3-yl}-1-methyl-1H-benzimidazole,

4-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-6-[3-(1-methyl-1H-benzimidazol-2-yl)azetidin-1-yl]pyrimidine-2-carbonitrile,

1-Methyl-2-(1-(2-methyl-6-(2-methylpyridin-3-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(pyridin-3-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(2-methoxypyridin-3-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

N-(3-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)pyridin-2-yl)acetamide,

2-(1-(6-(2-methoxy-6-methylpyridin-3-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(2-fluoro-6-methylpyridin-3-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(pyridin-4-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(6-(trifluoromethyl)pyridin-2-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-phenylpyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(2-methoxyphenyl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(2-fluorophenyl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(2-(difluoromethoxy)phenyl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)phenol,

2-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)benzoic acid,

1-methyl-2-(1-(2-methyl-6-(5-methylpyridin-2-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(pyridin-2-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(2-methoxy-6-(5-methylpyridin-2-yl)pyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-methyl-2-(1-(6-(5-methylpyridin-2-yl)-2-(trifluoromethyl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

1-methyl-2-(1-(2-methyl-6-(6-methylpyridin-2-yl)pyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(5-chloropyridin-2-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3-methoxypyridin-2-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-1H-benzo[d]imidazole,

1-(2-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)pyridin-4-yl)ethanone,

1-(6-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)pyridin-3-yl)ethanone,

6-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)nicotinonitrile,

2-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)oxazole,

2-(2-methyl-6-(3-(1-methyl-1H-benzo[d]imidazol-2-yl)azetidin-1-yl)pyrimidin-4-yl)thiazole,

1-methyl-2-{1-[2-methyl-6-(pyridazin-3-yl)pyrimidin-4-yl]azetidin-3-yl}-1H-benzimidazole,

2-(1-(6-(3,5-Dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-7-fluoro-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-6-fluoro-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-7-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-6-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-7-(trifluoromethyl)-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-6-(trifluoromethyl)-1H-benzo[d]imidazole,

2-(1-(6-(3,5-Dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-ethyl-1H-benzo[d]imidazole,

2-(2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazol-1-yl)acetonitrile,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-(2-fluoroethyl)-1H-benzo[d]imidazole,

2-(2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazol-1-yl)ethanol,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-propyl-1H-benzo[d]imidazole,

3-(2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazol-1-yl)propanenitrile,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-(2-ethoxyethyl)-1H-benzo[d]imidazole,

4-(2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1H-benzo[d]imidazol-1-yl)butanenitrile,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-4-fluoro-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-7-fluoro-1-methyl-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1,4-dimethyl-1H-benzo[d]imidazole,

2-(1-(6-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpyrimidin-4-yl)azetidin-3-yl)-1-methyl-4-(trifluoromethyl)-1H-benzo[d]imidazole,

4-(3,5-Dimethyl-1H-1,2,4-triazol-1-yl)-2-methyl-6-[3-(5-methylpyridin-2-yl)azetidin-1-yl]pyrimidine,

or a pharmaceutically acceptable salt thereof.

14. A pharmaceutical composition which comprises a pharmaceutically acceptable carrier and a compound of claim 1 or a pharmaceutically acceptable salt thereof.