SYSTEM AND STENT FOR REPAIRING ENDOVASCULAR DEFECTS AND METHODS OF USE
Disclosed are endovascular stents in which a portion of the stents have a bioactive coating for promoting repair of damaged vessels, systems comprising the stents, and methods of using the stents to promote occlusion of aneurysms and/or repair damaged vessels.
1 . A stent comprising a coating on a portion of its surface for use in the treatment of a cerebral aneurysm, the coating comprising:
a magnetic material deposited on portion of an outer surface of the stent;
an ion-beam nanostructured biocompatible layer; and
a bioactive layer formed on the biocompatible layer, the bioactive layer comprising PCSM.
2 . The stent of claim 2 , further comprising an underlayer between the outer surface of the stent and the magnetic material.
3 . The stent of any one of claim 1 or 2 , wherein the magnetic material is selected from a magnetic metal layer and a polymer impregnated with a magnetic metal.
4 . The stent of claim 4 , wherein the metal is nickel.
5 . The stent of claim 4 , wherein the polymer is bacterial nanocellulose.
6 . The stent of any of claims 1 - 5 , further comprising nanoscale particles embedded in the coating to provide radiation-enhanced tomography for visualization of the stent surface.
7 . A system for delivering a stent to a cerebral artery having an aneurysm comprising an endovascular catheter and the stent of any one of claims 1 - 6 .
8 . The system of claim 7 , further comprising magnetized cells.
9 . The system of claim 8 , wherein the magnetized cells are endothelial cells.
10 . A method of repairing a cerebral artery and/or occluding an aneurysm comprising:
delivering the stent of any one of claims 1 - 6 to the artery such that the portion of the stent comprising the coating is proximal to the aneurysm neck in need of repair and/or occlusion.
11 . The method of claim 10 , further comprising delivering magnetized cells to the region of the artery in need of repair.
12 . The method of claim 10 or 11 , wherein the stent is delivered to the artery in need of repair by catheterization.