PACKAGING FOR ALITRETINOIN
The present invention relates to the use of an oxygen absorber and silica gel desiccant in a vacuum-sealed pack for the reduction or prevention of oxidative degradation of alitretinoin.
1 . A method for the reduction or prevention of oxidative degradation of alitretinoin comprising an oxygen absorber and a silica gel desiccant in a vacuum-sealed pack.
2 . A vacuum-sealed pack comprising alitretinoin, an oxygen absorber and a silica gel desiccant.
3 . A vacuum-sealed pack comprising a pharmaceutical composition which includes alitretinoin, an oxygen absorber, and a silica gel desiccant.
4 . The vacuum-sealed pack of claim 1 , 2 , or 3 , wherein the oxygen absorber is an inorganic metal based oxygen absorber; an ascorbic acid based absorber; an enzymatic absorber; or a polymer based oxygen absorber.
5 . The vacuum-sealed pack of claim 1 , 2 , or 3 , wherein the oxygen absorber is StabilOx®.