IP Library › Granted Patent US 9,925,251
Granted Patent B2
US 9,925,251 · App. 14/352,440 · Granted Mar 27, 2018

Treatments for

Inventors: Tatos Akopian (West Roxbury, MA); Olga Kandror (Newton, MA); Alfred Lewis Goldberg (Brookline, MA); Ravikiran M. Raju (Cambridge, MA); Meera Unnikrishnan (Sienna, IT); Eric J. Rubin (Waban, MA)
Assignee: President and Fellows of Harvard College
A61K38/55A61K31/055A61K31/70A61K38/04A61K38/12A61K38/15A61K38/482A61K39/04A61K45/06C07K5/08C12N15/1137C12Q1/37C12Y304/21092C07K5/0821G01N2500/00
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Quick Facts
Patent No.
US 9,925,251
App. No.
14/352,440
Granted
Mar 27, 2018
Kind
B2
Abstract

The technology described herein relates to treatments for tuberculosis which target the ClpP1P2 protease complex, including ClpC1. Further embodiments relate to assays and screens for modulators of the ClpP1P2 protease complex, including ClpC1.

Claims (5)

1. A method of treating a Mycobacterium tuberculosis infection comprising administering, to a subject having a Mycobacterium tuberculosis infection, a composition comprising at least one of:

a) Novo23; or

b) a ClpP1 polypeptide comprising the amino acid sequence of SEQ ID NO: 1, wherein the amino acid sequence comprises a Ser98Ala or His123Ala mutation.

2. The method of claim 1 , further comprising administering to a subject a composition comprising a further antibiotic.

3. The method of claim 2 , wherein the antibiotic is an aminoglycoside.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 25, 2015
From: GOLDBERG, ALFRED L.; AKOPIAN, TATOS; KANDROR, OLGA; RAJU, RAVIKIRAN M.; RUBIN, ERIC JOSEPH; UNNIKRISHNAN, MEERA
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 035027/0329 →
CONFIRMATORY LICENSE Recorded Nov 17, 2014
From: HARVARD UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 034274/0199 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 8, 2014
From: AKOPIAN, TATOS; GOLDBERG, ALFRED L.; KANDROR, OLGA; RAJU, RAVIKIRAN M.; RUBIN, ERIC JOSEPH; UNNIKRISHNAN, MEERA
To: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
Reel/Frame 033911/0331 →
Continuity (3)
Provisional Application 61548983 · Oct 19, 2011
Provisional Application 61588421 · Jan 19, 2012
Related Publication 20140243255A1 · Aug 28, 2014