Nano-suspension process
View Patent ↗Described herein is a process for preparing nano-suspensions, wherein the process comprises: providing an admixture of at least one active pharmaceutical compound, an aqueous dispersion medium, and milling media and applying thereto acoustic energy having a frequency of from about 10 hertz to 1000 hertz and which supplies a linear acceleration of from about 10 G's to about 100 G's (where “G” is the force of gravity) for a period sufficient to supply a nano-suspension having a D 50 of less than about 1 micron, preferably less than about 500 nm. Described also are nano-suspensions having novel properties prepared via the inventive process.
1. A method of preparing a nano-suspension, the method comprising applying low frequency acoustic energy at a frequency of 60 Hertz to an admixture comprising: (i) an active pharmaceutical compound; (ii) an aqueous dispersion medium which includes a surface-active polymer and optionally includes a surfactant as a stabilizer; and (iii) milling media, wherein said acoustic energy is applied until said active pharmaceutical compound has been milled to the desired average diameter in the nanoparticle range.
2. The method of claim 1 , wherein the acoustic energy is applied as a standing wave.
3. The method of claim 2 wherein the acoustic energy imparts a force of from about 10 G to about 100 G.
4. A nano-suspension prepared in accordance with the method of claim 3 .
5. The nano-suspension of claim 4 wherein said nanoparticles comprise in excess of 75-99 wt % active pharmaceutical compound.
6. A process for preparing multiple nano-suspension samples simultaneously, the method comprising: (a) preparing in each chamber in a multi-chambered apparatus, an admixture comprising: (i) an active pharmaceutical compound; (ii) an aqueous dispersion medium; and (iii) a milling media; and (b) applying low frequency acoustic energy at a frequency of 60 Hertz to said multi-chambered apparatus until said drug particles have acquired the desired average diameter in the nanoparticle range.
7. The process of claim 6 wherein the acoustic energy is applied as a standing wave.
8. The process of claim 7 wherein the acoustic energy imparts a force of from about 10 G to about 100 G.
9. The method of claim 1 wherein the acoustic energy imparts a force of from about 10 G to about 100 G.
10. A nano-suspension prepared in accordance with the method of claim 1 .
11. A nano-suspension prepared in accordance with the method of claim 2 .
12. A nano-suspension prepared in accordance with the method of claim 3 .
13. The process of claim 6 wherein the acoustic energy is applied as a standing wave.
14. The process of claim 6 wherein the acoustic energy imparts a force of from about 10 G to about 100 G.