Systems and methods for intra-pulmonary percussive ventilation integrated in a ventilator

1. A respiratory therapy system comprising:

a pressure generator configured to generate a pressurized flow of breathable gas for delivery to the airway of a subject;

one or more sensors configured to generate one or more output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; and

one or more processors configured to execute computer program modules, the computer program modules comprising:

a therapy module configured to determine levels of one or more gas parameters of the pressurized flow of breathable gas as a function of time in accordance with a respiratory therapy regime;

a perturbation module configured (i) to determine one or more perturbation parameters defining perturbations to be applied to the levels of the one or more gas parameters determined by the therapy module and (ii) to output a perturbation parameter control signal, wherein one of the perturbation parameters includes a range of frequencies of perturbations that comprises frequencies higher than a frequency of common breathing rates to be applied as high-frequency fluctuations added to the levels of the one or more gas parameters;

a control module configured to control the pressure generator to adjust the one or more gas parameters of the pressurized flow of breathable gas such that the levels of the one or more gas parameters in the pressurized flow of breathable gas are the levels determined by the therapy module with the perturbations defined by the determined one or more perturbation parameters and applied as high-frequency fluctuations added to the determined levels; and

a breathing parameter determination module configured to determine breathing parameters and gas parameters based on (i) the one or more generated output signals of the one or more sensors and (ii) the perturbation parameters determined by the perturbation module, wherein the breathing parameter determination module is further configured to output a breathing parameter control signal in response to the determined breathing parameters and gas parameters,

wherein the control module is further configured to adjust, in response to the breathing parameter control signal, the levels of the one or more gas parameters in the pressurized flow of breathable gas, and

wherein the perturbation module further determines perturbation parameters defining perturbations selected from the group consisting of: (i) perturbations that gradually, across multiple respiratory cycles, sweep through the range of frequencies, (ii) perturbations having a randomly determined frequency within the range of frequencies for one or more respiratory cycles, and (iii) perturbations having a frequency determined according to one or more predetermined patterns.

2. The respiratory therapy system of claim 1 , wherein the breathing parameter determination module is further configured to determine a level of secretion retention from the one or more generated output signals, and wherein the perturbation module is configured to determine the one or more perturbation parameters further based on the determined level of secretion retention.

3. The respiratory therapy system of claim 1 , wherein the breathing parameters delineate inhalation phases and exhalation phases, and wherein the determinations of the therapy module and the perturbation module are determined separately for inhalation phases and exhalation phases.

4. The respiratory therapy system of claim 1 , wherein the control module is configured to control one or more of a volume of the pressurized flow of breathable gas or a pressure of the pressurized flow of breathable gas to which perturbations are added.

5. A method for providing respiratory therapy, the method comprising:

generating a pressurized flow of breathable gas for delivery to the airway of a subject;

generating one or more output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas;

determining levels of one or more gas parameters of the pressurized flow of breathable gas as a function of time in accordance with a respiratory therapy regime;

determining one or more perturbation parameters defining perturbations to be applied to the determined levels of the one or more gas parameters, wherein one of the perturbation parameters includes a range of frequencies of perturbations that comprises frequencies higher than a frequency of common breathing rates to be applied as high-frequency fluctuations added to the levels of the one or more gas parameters;

determining one or more breathing parameters and gas parameters based on (a) the one or more generated output signals and (b) the determined perturbation parameters and outputting a breathing parameter control signal in response to the determined breathing parameters and gas parameters; and

adjusting the one or more gas parameters of the pressurized flow of breathable gas such that the levels of the one or more gas parameters of the pressurized flow of breathable gas are the determined levels in accordance with the respiratory therapy regime with the perturbations defined by the determined one or more perturbation parameters and applied as high-frequency fluctuations added to the determined levels, and further adjusting, in response to the breathing parameter control signal, the levels of the one or more gas parameters in the pressurized flow of breathable gas, and

wherein determining the perturbation parameters further includes defining perturbations selected from the group consisting of: (i) perturbations that gradually, across multiple respiratory cycles, sweep through the range of frequencies, (ii) perturbations having a randomly determined frequency within the range of frequencies for one or more respiratory cycles, and (iii) perturbations having a frequency determined according to one or more predetermined patterns.

6. The method of claim 5 , wherein determining the one or more breathing parameters includes determining a level of secretion retention from the one or more generated output signals, and wherein determining the one or more perturbation parameters is further based on the determined level of secretion retention.

7. The method of claim 5 , wherein the one or more breathing parameters delineate inhalation phases and exhalation phases, and wherein adjusting the one or more gas parameters of the pressurized flow of breathable gas is performed separately for inhalation phases and exhalation phases.

8. The method of claim 5 , wherein the one or more gas parameters of the pressurized flow of breathable gas include one or more of a volume of the pressurized flow of breathable gas or a pressure of the pressurized flow of breathable gas to which perturbations are added.

9. A system for providing respiratory therapy, the system comprising:

means for generating a pressurized flow of breathable gas for delivery to the airway of a subject;

means for generating one or more output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas;

means for determining levels of one or more gas parameters of the pressurized flow of breathable gas as a function of time in accordance with a respiratory therapy regime;

means for determining one or more perturbation parameters defining perturbations to be applied to the determined levels of the one or more gas parameters and for outputting a perturbation parameter control signal, wherein one of the perturbation parameters includes a range of frequencies of perturbations that comprises frequencies higher than a frequency of common breathing rates to be applied as high-frequency fluctuations added to the levels of the one or more gas parameters;

means for determining breathing parameters and gas parameters based on (i) the one or more generated output signals and (ii) the determined perturbation parameters, wherein the determining means is further for outputting a breathing parameter control signal in response to the determined breathing parameters and gas parameters; and

means for adjusting the one or more gas parameters of the pressurized flow of breathable gas such that the levels of the one or more gas parameters of the pressurized flow of breathable gas are the determined levels in accordance with the respiratory therapy regime with the perturbations defined by the determined one or more perturbation parameters and applied as high-frequency fluctuations added to the determined levels,

wherein the adjusting means is further configured to adjust, in response to the breathing parameter control signal, the levels of the one or more gas parameters in the pressurized flow of breathable gas, and

wherein the perturbation determining means further determines perturbation parameters defining perturbations selected from the group consisting of: (i) perturbations that gradually, across multiple respiratory cycles, sweep through the range of frequencies, (ii) perturbations having a randomly determined frequency within the range of frequencies for one or more respiratory cycles, and (iii) perturbations having a frequency determined according to one or more predetermined patterns.

10. The system of claim 9 , wherein the means for determining the one or more breathing parameters further performs a determination of a level of secretion retention from the one or more generated output signals, and wherein operation of the means for determining the one or more perturbation parameters is further based on the determination of the level of secretion retention.

11. The system of claim 9 , wherein the one or more breathing parameters delineate inhalation phases and exhalation phases, and wherein operation of the means for adjusting the one or more gas parameters of the pressurized flow of breathable gas is performed separately for inhalation phases and exhalation phases.

12. The system of claim 9 , wherein the one or more gas parameters of the pressurized flow of breathable gas include one or more of a volume of the pressurized flow of breathable gas or a pressure of the pressurized flow of breathable gas to which perturbations are added.