Methods of treating cancer with herbacetin
The invention provides methods, uses and compounds for treating cancers. For example, certain embodiments provide a method for treating cancer in a mammal comprising administering to the mammal an effective amount of 3,5,7,8,4′-Pentahydroxyflavone, or a pharmaceutically acceptable salt thereof. Certain other embodiments of the invention provide methods for inactivating ornithine decarboxylase (ODC) in a cell comprising contacting the cell in vitro or in vivo with an effective amount of 3,5,7,8,4′-Pentahydroxyflavone, or a pharmaceutically acceptable salt thereof. The invention also provides a dermal product comprising 3,5,7,8,4′-Pentahydroxyflavone, or a pharmaceutically acceptable salt thereof, wherein the product prophylactically or therapeutically treats sunburn or other sun exposure and/or skin cancer in a mammal.
1. A method for inactivating ornithine decarboxylase (ODC) in a cell comprising contacting the cell in vitro or in vivo with an effective amount of 3,5,7,8,4′-Pentahydroxyflavone, or a pharmaceutically acceptable salt thereof.
2. A method for inhibiting cancer cell growth comprising contacting the cell in vitro or in vivo with an effective amount of 3,5,7,8,4′-Pentahydroxyflavone, or a pharmaceutically acceptable salt thereof.
3. A method for treating cancer in a mammal comprising administering to the mammal an effective amount of 3,5,7,8,4′-Pentahydroxyflavone, or a pharmaceutically acceptable salt thereof.
4. The method of claim 3 , wherein the mammal is in need of such treatment.
5. The method of claim 3 , wherein the mammal is diagnosed with cancer.
6. The method of claim 3 , wherein the mammal is a human.
7. The method of claim 3 , wherein the cancer is colon cancer or skin cancer.
8. A dermal product comprising 3,5,7,8,4′-Pentahydroxyflavone, or a pharmaceutically acceptable salt thereof, wherein the product prophylactically or therapeutically treats sunburn or other sun exposure and/or skin cancer in a mammal.
9. The product of claim 8 , wherein the product is a sunscreen.