Targets of
The present invention provides antigenic polypeptides expressed during an infection by a pathogenic organism, such as Acinetobacter and compositions comprising these polypeptides. The invention further provides compositions for use in treating, preventing or detecting a bacterial infection, in particular vaccine compositions using the antigenic polypeptides. The invention further provides antibodies directed to said antigenic polypeptides.
1. An antibody that specifically binds to the epitope consensus motif PVDFTVAI shown in SEQ ID NO: 36;
wherein said antibody is an IgG capable of inducing an effector function towards Acinetobacter baumannii.
2. An antibody or antigen-binding fragment thereof that specifically binds to the epitope consensus motif PVDFTVAI (SEQ ID NO: 36).
3. The antibody of claim 2 , wherein the antibody is human.
4. The antigen-binding fragment of claim 2 .
5. An eukaryotic expression host cell capable of producing the antibody of claim 2 .
6. A hybridoma capable of producing the antibody of claim 2 .